INFLUENCE OF THERAPY WITH FIXED COMBINATION OF PERINDOPRIL AND AMLODIPINE ON PARAMETERS OF ELASTICITY OF MAIN VESSELS AND MICROCIRCULATION IN PATIENTS WITH ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUS

摘要

Objective: to assess in patients with arterial hypertension and type 2 diabetes the effect of perindopril/amlodipine fixed combination on arterial wall stiffness (AWF) and microcirculation, and relationship between AWF parameters and the state microcirculation. Materials and methods. We included in this study 30 patients aged 45-65 years. All patients received fixed perindopril arginine/amlodipine besylate combination for 12 weeks. Examination included measurement of AWF of main arterial blood vessels and evaluation of the state of microcirculation. Results. Target blood pressure was achieved in 100% of patients. Mean values of pulse wave velocity of elastic and muscle-type vessels decreased by 8.5 and 10.3%, respectively; number of patients with paradoxical test also significantly decreased (p>0.05). Shunting index and myogenic tone significantly decreased by 21 and 33.6%, respectively. We also observed significant reduction of endothelium-dependent tone component (Delta%=36.3%), significant rise of mean value of perfusion (Delta%=19.7%), and significant increase of the respiratory test index (Delta%-=4.5%). There was a statistically significant redistribution of patients by types of microcirculation: the percentage of patients with hyperemic type increased from 26.7 to 43.3%. Conclusion. In patients with arterial hypertension and type 2 diabetes mellitus perindopril arginine/amlodipine besylate fixed combination demonstrated high antihypertensive efficacy, positive effect on parameters of elasticity of main vessels and microcirculation.