Quantification of wall shear stress in large blood vessels using magnetic resonance imaging

摘要

Wall shear stress (WSS) quantifies the frictional force that flowing blood exerts on a vessel wall. Magnetic Resonance Imaging (MRI) enables non-invasive measurements of blood flow velocities that are needed for WSS computation. An introduction into MRI-based WSS quantification in large blood vessels is presented. The possible role of WSS as a potential biomarker in cardiovascular diseases, cardiovascular MRI, MR-based WSS quantification methods, and their accuracy and validation are considered. As an example, the generic nonlinear regression method for MRI-derived WSS quantification in fully developed turbulent stationary pipe flows is presented. The new method is a fully automatic and fast local WSS estimator, which produces accurate estimates independent from the spatial resolution of the measurement and may serve as a reliable reference for validation of more generic WSS estimators prior to their clinical applications.