Anti-inflammatory Activity of Petalonia binghamiae on Acute Inflammation in Animal Models

摘要

Objectives Chronic inflammation is thought to be a significant factor for various diseases including Alzheimer's, arthritis, cancer, diabetes, and heart disease. Although there are several anti-inflammatory drugs, these drugs show severe side-effects. Therefore, it is important to find new food materials with anti-inflammatory effects instead of drugs. In this study, we investigated the anti-inflammatory effect of the sea alga Petalonia binghamiae (P. binghamiae) in vivo and in vitro.Methods P. binghamiae was extracted with methanol (PBE). The anti-inflammatory effect of PBE (1000 and 2000 mg/kg body weight) was evaluated on a carrageenan-induced paw edema model in mice. The levels of nitric oxide (NO) production stimulated by lipopolysaccharides (LPS) were measured in RAW264.7 macrophages with or without PBE. Results We found that oral treatment with 2000 mg/kg body weight of PBE had a significant inhibitory effect in carrageenan-induced paw edema model mice. We also found that the treatment of PBE (6.25, 12.5 25, 50,100, and 200 jug/mh) decreased the levels of NO production stimulated by LPS in RAW264.7 macrophages without being cytotoxic.Conclusion Our results suggest that P. binghamiae potentially has a role in an anti-inflammatory effect, and it could be useful as a functional food for prevention of chronic inflammatory disease.