Re: 'Age dependence of the risk of intussusception following tetravalent rhesus-human reassortant rotavirus tetravalent vaccine: is it beyond doubt?'.

摘要

In their recent article on age and risk of intussusception following rhesus-human reassortant rotavirus tetravalent vaccine (RRV-TV), Chen et al. stated, "The restricted quadratic smoothing spline with appropriately chosen knot locations showed a statistically significant increased risk of intussusception associated with RRV-TV for the exposure window 3-14 days after the first dose at an age as young as 49 days, the youngest age in the data set at which the vaccine was administered; this implies an increased risk of intussusception associated with RRV-TV at all ages studied" (1, p. 1046).