SAGE EXTRACT ENTRAPPED IN NANOSTRUCTURED LIPID CARRIERS FOR APPLICATION INTO THE MOUTH CAVITY FOR ORAL HYGIENE

摘要

Sage extract from Salvia officinalis L. (Lamiaceae) has a wide variety of biological activities to be used in mouthwashes and gargles in disorders of the mouth cavity, throat and respiratory system. Sage extract was purposed to be incorporated into nanostructured lipid carriers for hygiene and freshness of oral cavity in daily use, and for reducing oral flora and pH to assist in the re-epithelialization of the mucosa especially for surgical patients under nursing care. Nanostructured lipid carriers which combine various benefits including high payload of actives and controlled drug delivery, were produced by high pressure homogenization technique. Dexpanthenol and chlorhexidine digluconate were also added to the formulations. Nanoemulsions were also produced by the same technique for comparison. Photon correlation spectroscopy and laser diffraction were used for particle size measurements of nanoparticles and nanoemulsions. Nanostructured lipid carriers were obtained in the nanometer size range lower than 260 nm. Formulations containing dexpanthenol and chlorhexidine digluconate were tested in the descriptive type of subjective test on volunteers by spraying into their mouth cavity. Nanostructured lipid carriers containing the highest amounts of sage extract and lipid displayed the longest effect according to the descriptive type of subjective test indicating sustained sage extract delivery (p<0.05).