Acute generalized exanthematous pustulosis: a rare clinical entity with use of piperacillin/tazobactam.

摘要

Acute generalized exanthematous pustulosis (AGEP) is a rare disorder characterized by an acute episode and sudden onset of erythematous and edematous eruptions of hundreds of sterile pustules. It is a self-limiting condition accompanied by fever and has a rapid course. It is mostly caused by drugs especially antibiotics. It is diagnosed by skin biopsy, which shows intracorneal pustules and neutrophilic infiltration in dermis and epidermis. We report a case of a patient who developed this rare skin condition with the use of piperacillin/tazobactam (Zosyn). This is only second case of AGEP reported in literature with the use of Zosyn.