Genotyping of drug metabolizing enzymes,drug transporters,and drug receptores for individualization of drug therapy

摘要

The human genome project has been almost completed in 200,and a humber of postgenomic studies will be conducted in the next decade.Efficacy and adverse events following any kind of therapy incluidng drug administration would be predicted from genetic characteristics of individulas.In this presentation,we will introduce our investigations concerning 1)CYP2C19 genotype-related efficacy in anti-H-pylori therapy,2)NAT2 genotype-related PK of procainamide,isoniazide and sulfsarazine,3)MDR1 genotype-related digoxin PK,and 4)#beta#2-adrenergic receptor genotyp-related desensitization to #beta#2-agonist.