The Investigation of cis- and trans-Interactions Between Claudins

摘要

Claudins control the paracellular permeability of the tight junctions in epithelial and endothelial cells forming single cell layers. Several claudins ma y constitute a network of strands, establishing a continuous barrier within the intercellular clefts of the monolayer. Depending on the claudin composition bf a given tissue, the intracellular space may be tight for any solute or permeable for compounds of different molecular weight or differently charged ions.