Deactivation of murine alveolar macrophages by peroxisome proliferator-activated receptor-7 ligands

摘要

Peroxisome proliferator-activated receptor-7 (PPAR-7), a member of the nuclear hormone receptor family of ligand-dependent transcription factors, is a critical regulator of adipocyte differentiation and glucose metabolism. The expression, regulation, and functional significance of PPAR-7 in alveolar macrophages (AMs), the predominant resident immune effector cell within the alveolus, have not been previously examined. In this study, we show that, in contrast to peritoneal macrophages, resident murine AMs constitutively express high levels of PPAR-gamma.