JSNP Excellent Presentation Award for CINP2014: Reduced Supraspinal Nociceptive Responses and Distinct Gene Expression Profile in CXBH Recombinant Inbred Mice

摘要

Pain sensation is an essential sensory modality that protects the body from excessive nociceptive stimuli and ftirther injury. However, considerable variability exists in the sensitivity to pain across individuals, which has been an unresolved clinical issue in pain management.Numerous polymorphisms in the human genes are reportedly associated with interindividual differences in pain-and analgesic-related clinical traits (Kasai and Dceda, 2011). Genetic factors mainly cause variability between inbred strains because these animals are isogenic within each strain, barring title very rare occurrence of a new mutation. Therefore, the use of inbred animals has been an effective strategy for investigating the heritability of traits associated with interindividual differences. To date, various inbred and recombinant inbred mouse strains have been established, and interstrain differences among inbred strains have been reported in nociception and atttinociception (Shigeta et al, 2008).