Predicting Dopamine D2 Receptor Occupancy Following Antipsychotic Dose Reduction: A Pilot PET Study

摘要

Position emission tomography (PET) studies have demonstrated that a therapeutic window of striatal dopamine D2 receptor occupancy (65-80%) is associated with clinical response for most antipsychotic drugs in younger adults (Farde et al,1995; Kapur et al,2000). This observation has been used to predict the therapeutic dose range of new drugs and has contributed to cuixent recommended antipsychotic dose range. However, unfortunately, measuring dopamine D2 occupancy levels with brain imaging techniques such as PET is not feasible for clinical purposes due to lack of wide availability and its high cost. Therefore, dose adjustment has always been associated with difficulties and currently been performed, relying on a trial-and-error strategy that carries a risk of relapse and adverse effects (Uclnda et al, 2009).