In this issue of AJKD, Grams et al1 report new information regarding the secular trend in chronic kidney disease (CKD) prevalence in the US population by comparing the prevalence of reduced cystatin C estimated glomerular nitration rate (eGFR) in 2 survey periods spanning more than a decade: NHANES m (Third National Health and Nutrition Examination Survey; 1988-1994) and NHANES 1999-2002. Compared with prior studies (Table 1), this article's novel contributions include the use of cystatin C as filtration marker after alignment of calibration in the 2 survey periods and use of the latest cystatin C GFR estimating equations.
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