Kidney Disease in Childhood-Onset Diabetes

摘要

The increasing prevalence of obesity in children and adolescents in many parts of the world is strongly implicated in the increasing incidence of type 1 and type 2 diabetes during childhood. Whether youth affords some protection from the vascular complications of diabetes is uncertain, but the importance of this question is clear given the major public health and economic impact associated with earlier development of diabetic complications, including kidney disease. Some studies suggested that the prepu-bertal years of diabetes contribute less to the risk of diabetic kidney disease than the postpu-bertal years; however, this concept is controversial. Nevertheless, up to 40% of persons with type 1 diabetes develop overt diabetic nephropathy within 20 to 25 years of the onset of diabetes.