Urinary tubular biomarkers of kidney damage: potential value in clinical practice.

摘要

Chronic kidney disease (CKD) is a worldwide public health problem leading to a steadily increasing number of patients with end-stage renal disease. According to current guidelines, renoprotective intervention aims at decreasing blood pressure and proteinuria. Whereas proteinuria reduction is a main predictor for long-term outcome, this predictive value is far from perfect because even responders to antipro-teinuric treatment may still show progressive loss of kidney function.