HAIR RESTORATION EFFICACY OF SUPPLEMENTS CONTAINING BANANA EXTRACT, PARTHENOLIDE DERIVED FROM FEVERFEW AND SOY ISOFLAVONE IN HEALTHY JAPANESE A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY —

摘要

Objective: The objective of this research was to investigate the effectiveness of daily ingestion of a capsule, which contains banana extract, parthenolide derived from Feverfew, and soy isoflavone on hair growth. Methods： A randomized, placebo-controlled, double-blind study was conducted. To evaluate, the thickness of the hair, the level of sebum around the pore, 6 indexes to score the condition of the scalp (inflammation, rash, amount of dandruff, pore-clogging, sebum capacity and dryness) and the physicians assessments of the change in scalp coverage were measured. Results- From all of 83 applicants, 43 were eliminated according to the Hamilton's index of thinning hair (for males), or according to the modified Ludwig Type (for females). Among 40 subjects, 4 were withdrawn due to illness or business, and the remaining 36 subjects completed the study (MO = 16: M;8， F;8， Placebo = 20: M;，11, F;9). After 12 weeks ingestion, the study showed significant improvement in "the level of sebum around the pore", "the condition of the scalp, including amount of dandruff, pore-clogging, and sebum capacity", and the physicians assessments of scalp coverage . The result of self-assessment also showed the significant improvement in many items related to hair loss. No adverse effects were observed after the ingestion of the test product. Conclusion： We found out that, compared with Placebo, the ingestion of the supplement containing banana extract (cycloeucalenone), parthenolide derived from Feverfew, and soy isoflavone for 12 weeks contributed to hair restoration, which is achieved by the improvement of scalp conditions such as pore-clogging, dandruff, and/or itcnmg, and by reducing hair loss. In addition, no safety-related matters occurred during the 12-week test period.