Factors interfering with CRP assay and various methods of producing reagents that avoid some interference factors

摘要

Recently, our customers have demanded highly precise methods of CRP assay, since the significance of quantitative analysis using very low concentration of CRP has been reevaluated. We must very carefully develop additional devices and produce new reagents, in order to avoid some interference factors to CRP assay. We will explain our process for development of reagents and various ideas to avoid such interference factors, as follows. i.e. 1. selection of latex, 2. selection of antibody, 3. selection of the sensitization methods. We will be able to produce high performance reagents that can avoid some interference factors using procedures. However, after launching the reagents, we sometimes receive complaints that a particular reagent may be influenced by unknown factors that were not anticipated the development stage. We will explain the way that we confirmed unknown factors and our efforts to discover the causes of the interference with our products in that case.