Gaining: Pediatric Patients and Use of Atypical Antipsychotics

摘要

In this edition of the Journal, Klein and co-workers present a treatment trial showing benefits of metformin for children and adolescents who experienced rapid weight gain, a risk factor for type II diabetes, while taking atypical antipsychotic medications. A placebo-controlled study in adults (1) and an open trial in children (2) have appeared, but this is the first double-blind, placebo-controlled trial in pediatric patients taking atypical antipsychotics.