Varenicline withdrawal-induced delirium with psychosis.

摘要

To the Editor: Varenicline has had promising results for smoking cessation but is associated with psychiatric side effects. As of August 2009, there have been several published reports of suspected varenicline-induced mania or psychosis (1-3), including one case of withdrawal-related hallucinations (4). Pfizer's website lists dissociation, disorientation, and abnormal thinking as possible adverse reactions. In 2008, the Federal Aviation Administration banned the use of varenicline for airline pilots and air traffic controllers because of a Food and Drug Administration (FDA) public health advisory and a report by the Institute for Safe Medication Practices describing psychosis and visual changes as possible side effects. In July 2009, the FDA mandated a boxed warning for the drug. This is the first case report of withdrawal-induced delirium.