2009 in review.

摘要

Early Change in Negative Bias After Antidepressant Treatment:Harmer et al. (1) advocate a new strategy for drug discovery in depression. Their article illustrates how the use of intermediate phenomenology outcomes could expedite drug discovery for depression; moreover, the report demonstrates how basic cognitive neu-roscience can be useful in understanding and treating brain diseases. Cognitive neuro-science developed the concept of "negative bias" in information processing, a situation where more negative than positive emotional information is extracted from a stimulus. The authors used three sophisticated emotional tasks developed within cognitive neu-roscience to demonstrate several different aspects of negative bias in a set of depressed and comparison volunteers.