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Wassily Kandinsky, 1866-1944

机译:瓦西里·康定斯基(Wassily Kandinsky),1866-1944年

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The dorsal cochlear nucleus (DCN) is a brainstem structure that receives input from the auditory nerve. Many studies in a diversity of species have shown that the DCN has a laminar organization and identifiable neuron types with predictable synaptic relations to each other. In contrast, studies on the human DCN have found a less distinct laminar organization and fewer cell types, although there has been disagreement among studies in how to characterize laminar organization and which of the cell types identified in other animals are also present in humans. We have reexamined DCN organization in the human using immunohistochemistry to analyze the expression of several proteins that have been useful in delineating the neurochemical organization of other brainstem structures in humans: nonphosphorylated neurofilament protein (NPNFP), nitric oxide synthase (nNOS), and three calcium-binding proteins. The results for humans suggest a laminar organization with only two layers, and the presence of large projection neurons that are enriched in NPNFP. We did not observe evidence in humans of the inhibitory interneurons that have been described in the cat and rodent DCN. To compare humans and other animals directly we used immunohistochemistry to examine the DCN in the macaque monkey, the cat, and three rodents. We found similarities between macaque monkey and human in the expression of NPNFP and nNOS, and unexpected differences among species in the patterns of expression of the calcium-binding proteins. Anat Rec, 297:1865-1884, 2014.
机译:耳蜗背侧核(DCN)是一种脑干结构,可接收来自听神经的输入。多种物种的许多研究表明,DCN具有层状组织,并且可识别的神经元类型之间具有可预测的突触关系。相比之下,对人类DCN的研究发现层状组织较少,细胞类型较少,尽管在如何表征层状组织以及人类中还存在其他动物中鉴定出的哪些细胞类型的研究之间存在分歧。我们已经使用免疫组织化学重新检查了人类的DCN组织,以分析可用于描述人类其他脑干结构的神经化学组织的几种蛋白质的表达:非磷酸化神经丝蛋白(NPNFP),一氧化氮合酶(nNOS)和三个钙结合蛋白。对人类的结果表明,层状组织只有两层,并且存在富含NPNFP的大投射神经元。我们没有在人类中观察到猫和啮齿类动物DCN中描述的抑制性中间神经元的证据。为了直接比较人类和其他动物,我们使用免疫组织化学检查了猕猴,猫和三只啮齿动物的DCN。我们发现猕猴和人类在NPNFP和nNOS的表达上有相似之处,并且在钙结合蛋白的表达方式上物种之间存在出乎意料的差异。 Anat Rec,297:1865-1884,2014。

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