Risk of upper gastrointestinal bleeding when taking ssris with nsaids or aspirin

摘要

To the Editor: In the January issue of the Journal, Wang et al. (1) reported more upper gastrointestinal bleeding risk in patients taking the combination of selective serotonin reup-take inhibitors (SSRIs) and nonsteroidal anti-inflammatory drugs (NSAIDs) than SSRIs combined with aspirin (adjusted odds ratios, 3.44 compared with 2.07). However, the data from the previous study by Dall et al. in 2009 (2) revealed that the stratum-specific odds ratio of upper gastrointestinal bleeding when combining SSRIs with NSAIDs or aspirin was the opposite (adjusted odds ratios, 1.79 compared with 2.2).