Discrepancy in response and remission rates for SAMe-treated patients in a double-blind, randomized clinical trial.

摘要

To the Editor: In the August 2010 issue of the Journal, George I. Papakostas, M.D., et al. (1), appear to have inadvertently made a calculation error, which has affected the results of their data. The authors stated that "response rates for SAMe-treated patients versus placebo-treated patients were 36.1% versus 17.6%, respectively, while remission rates were 25.8% versus 11.7%, respectively" (1, p. 946).Our calculations, based on the data presented in the article, are inconsistent with the aforementioned percentages. The quoted percentage is 36.1% for SAMe plus antidepressant treatment among responders, whereas the actual number of responders indicated on page 945 is 18/39, or 46.1%.