Glutamate Metabolism in Major Depressive Disorder

摘要

Objective: Emerging evidence suggests that abnormalities in amino acid neurotransmitter function and impaired energy metabolism contribute to the underlying pathophysiology of major depressive disorder. To test whether impairments in energetics and glutamate neurotransmitter cycling are present in major depression, we used carbon-13 magnetic resonance spectroscopy (C-13 MRS) to measure these fluxes in individuals diagnosed with major depression relative to healthy comparison subjects.