Controlled Release: A New Paradigm with Polyvinyl Acetate Polymer

摘要

Controlled release (CR) has been a subject of continued interest, and the pharma industry is taking a closer look into release profiles of drugs because of risk factors associated with early release (dose dumping) before being delivered to intended sites to achieve the desired efficacy, and to overcome toxicity and drug abuse issues. The latter has become more challenging, especially, in controlled delivery of opioids in pain management.12 Nonetheless, the former one is also poorly understood because of complexity associated with the mechanism of controlled release from a particular dosage.