首页> 外文期刊>Alternatives to laboratory animals: ATLA >The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM): a review of the ICCVAM test method evaluation process and current international collaborations with the European Centre for the Validation of Alternative Method
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The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM): a review of the ICCVAM test method evaluation process and current international collaborations with the European Centre for the Validation of Alternative Method

机译:替代方法验证机构间协调委员会(ICCVAM):ICCVAM测试方法评估流程的审查以及与欧洲替代方法验证中心的当前国际合作

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Over the last decade, national authorities in the USA and Europe have launched initiatives to validate new and improved toxicological test methods. In the USA, the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and its supporting National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) were established by the Federal Government to work with test developers and Federal agencies to facilitate the validation, review, and adoption of new scientifically sound test methods, including alternatives that can refine, reduce, and replace animal use. In Europe, the European Centre for the Validation of Alternative Methods (ECVAM) was established to conduct validation studies on alternative test methods. Despite differences in organisational structure and processes, both organisations seek to achieve the adoption and use of alternative test methods. Accordingly, both have adopted similar validation and regulatory acceptance criteria. Collaborations and processes have also evolved to facilitate the international adoption of new test methods recommended by ECVAM and ICCVAM. These collaborations involve the sharing of expertise and data for test-method workshops and independent scientific peer reviews, and the adoption of processes to expedite the consideration of test methods already reviewed by the other organisation. More recently, NICEATM and ECVAM initiated a joint international validation study on in vitro methods for assessing acute systemic toxicity. These collaborations are expected to contribute to accelerated international adoption of harmonised new test methods that will support improved public health and provide for reduced and more-humane use of laboratory animals.
机译:在过去的十年中,美国和欧洲的国家主管部门已经启动了旨在验证新的和改进的毒理学测试方法的计划。在美国,联邦政府成立了替代方法验证机构间协调委员会(ICCVAM)及其支持的国家毒理学计划替代毒理学方法评估机构间中心(NICEATM),与测试开发商和联邦机构合作,促进验证,审查和采用新的科学合理的测试方法,包括可以完善,减少和替代动物用途的替代方法。在欧洲,建立了欧洲替代方法验证中心(ECVAM),以进行替代测试方法的验证研究。尽管组织结构和流程存在差异,但两个组织都力求实现采用和使用替代测试方法的方法。因此,两者都采用了类似的验证和监管接受标准。合作和流程也不断发展,以促进ECVAM和ICCVAM建议的新测试方法的国际采用。这些合作包括共享测试方法研讨会和独立的科学同行评审的专业知识和数据,以及采用流程来加快对其他组织已经评审过的测试方法的考虑。最近,NICEATM和ECVAM发起了一项关于评估急性全身毒性的体外方法的国际联合验证研究。预计这些合作将有助于加速国际上采用统一的新测试方法,这将有助于改善公共卫生,并减少和更人性化地使用实验动物。

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