Small Particles, Large Scale: An Efficient Platform for Open-Access Fast LC on a Global Scale

摘要

Two common approaches to sample analysis exist in the pharmaceutical industry. Drug discovery organizations often employ open-access analysis, in which medicinal chemists submit their samples to automated analytical instrumentation and the analysis and reporting is performed automatically. The instrument is a shared resource used by multiple scientists. By contrast, pharmaceutical development organizations heavily favor custom analyses carried out by skilled analytical chemists using instruments dedicated to the exclusive use of a small number of analysts or projects. While NMR and LC-MS are frequently used as self-service, open-access instruments in both discovery and development, the vast majority of HPLC-UV analyses in development have not employed the open-access approach.