Periodate oxidation in chemistry of nucleic acids: dialdehyde derivatives of nucleosides, nucleotides, and oligonucleotides (review)

摘要

The employment of periodate oxidation in the chemistry of nucleic acids and their components is reviewed. The reaction mechanism, structural requirements to substrates, and synthesis of dialdehyde derivatives of nucleosides, nucleotides, and oligonucleotides are discussed in the first part. The second part involves chemical, physicochemical, and biological properties of the dialdehyde derivatives, as well as their use for the affinity modefications of proteins.