Resolution of 2-phenoxy-1-propanols by Pseudomonas sp. lipase-catalyzedhighly enantioselective transesterification: influence of reactionconditions on the enantioselectivity toward primary alcohols

摘要

2-Phenoxy-1-propanols were resolved using Pseudomonas sp. lipase with E (enantiomeric ratio) values of greater than or equal to 15. The enantioselectivity was highest with vinyl acetate and became lower with the chain length of the fatty acid moiety of acyl donors. It was improved with decreasing temperature. A linear direct correlation was observed between -RTlnE and the temperature of the reaction.