FBCA, A Multiscale Modeling Framework Combining Cellular Automata and Flux Balance Analysis

摘要

Multiscale computational models are powerful instruments to investigate the properties of biological systems, provide explanations about their complex behaviours and predict their likely future evolution. We here investigate the relation among the metabolic properties of cells and the emerging population dynamics of multi-cellular systems, such as tissues and organs, especially in abnormal circumstances, such as cancer origination and development.