A pilot study to establish human T‐cell leukemia virus type 1 (HTLV‐1) carrier model using common marmoset (        <i >Callithrix jacchusCallithrix jacchus        )

Hirose Lisa; Hiramoto Takafumi; Tian Yamin; Kohara Hiroshi; Kobayashi Seiichiro; Nagai Etsuko; Denda Tamami; Tanaka Yukihisa; Ota Yasunori; Jiyuan Liao; Miyamoto Shohei; Miura Yoshie; Hijikata Yasuki; Soda Yasushi; Inoue Takashi; Okahara Norio; Itoh Toshio; Sasaki Erika; Tojo Arinobu; Uchimaru Kaoru; Tani Kenzaburo

摘要

Abstract <section xml:id="jmp12454-sec-0001"> <title type="main">Background > For the diagnosis and treatment of adult T‐cell leukemia/lymphoma (ATLL) caused by human T‐lymphotropic virus type 1 (HTLV‐1) are required therapeutic modalities urgently. Non‐human primate models for ATLL would provide a valuable information for clinical studies. We did a pilot study to establish an ATLL non‐human primate model using common marmosets ( Callithrix jacchus ). </section> <section xml:id="jmp12454-sec-0002"> <title type="main">Methods >We inoculated HTLV‐1–producing MT‐2 cells into 9‐month‐old marmosets, either intraperitoneally or intravenously. We next administrated MT‐2 cells into 13‐month‐old marmosets under cyclosporine A (CsA) treatment to promote infection. HTLV‐1 infection was determined by measuring HTLV‐1 antibody titer in the common marmosets. </section> <section xml:id="jmp12454-sec-0003"> <title type="main">Results >The HTLV‐1 antibody titer increased in the intraperitoneally inoculated marmoset with or without CsA treatment, and it kept over five 5?years though proviral copy number (proviral load, PVL) remained low throughout the study. </section> <section xml:id="jmp12454-sec-0004"> <title type="main">Conclusion >We obtained HTLV‐1 asymptomatic carriers of common marmosets by inoculating MT‐2 cells. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：ID =“JMP12454-ABS-ABS-ABS-0001”XML：LANG =“EN” <标题类型=“main”>抽象</ title> <第XML：ID =“JMP12454-SEC-0001”> <title type =“main”>背景</ title> > 对于由人T型淋巴细胞病毒1型（HTLV-1）引起的成人T细胞白血病/淋巴瘤（ATLL）的诊断和治疗是必需的治疗方式迫切。 Alll的非人类灵长类动物模型将为临床研究提供有价值的信息。我们做了试验研究，使用常见的Marmosets建立ATLL非人类灵长类动物模型（ callithrix jacchus </ i> ）。 </ p> </部分> <第XML：ID =“JMP12454-SEC-0002”> <标题类型=“main”>方法</ title> >我们将HTLV-1产生的HTLV-1产生MT-2细胞进入9个月大的Marmosets，腹膜内或静脉内。我们将MT-2细胞施入13个月大的Marmosets，在环孢菌素A（CSA）治疗下以促进感染。通过测量常见的marmosets中的HTLV-1抗体滴度来确定HTLV-1感染。</ p> </部分> <第XML：ID =“JMP12454-SEC-0003”> <标题类型=“main”>结果</ title> > HTLV-1抗体滴度在有或没有CSA治疗的腹膜内接种的marmoset中增加，并且它在整个研究中保持较低的荧光拷贝数（透过载荷，PVL）持续超过五年。</ p> </部分> <第XML：ID =“JMP12454-SEC-0004”> <标题类型=“main”>结论</ title> 我们通过接种MT-2细胞获得常见Marmosets的HTLV-1无症状载体。</ p> </部分> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-36449/'>《Journal of medical primatology》</a> <b style="margin: 0 2px;">|</b><span>2020年第2期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hirose Lisa&option=202" target="_blank" rel="nofollow">Hirose Lisa;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hiramoto Takafumi&option=202" target="_blank" rel="nofollow">Hiramoto Takafumi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tian Yamin&option=202" target="_blank" rel="nofollow">Tian Yamin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kohara Hiroshi&option=202" target="_blank" rel="nofollow">Kohara Hiroshi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kobayashi Seiichiro&option=202" target="_blank" rel="nofollow">Kobayashi Seiichiro;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nagai Etsuko&option=202" target="_blank" rel="nofollow">Nagai Etsuko;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Denda Tamami&option=202" target="_blank" rel="nofollow">Denda Tamami;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tanaka Yukihisa&option=202" target="_blank" rel="nofollow">Tanaka Yukihisa;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ota Yasunori&option=202" target="_blank" rel="nofollow">Ota Yasunori;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jiyuan Liao&option=202" target="_blank" rel="nofollow">Jiyuan Liao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Miyamoto Shohei&option=202" target="_blank" rel="nofollow">Miyamoto Shohei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Miura Yoshie&option=202" target="_blank" rel="nofollow">Miura Yoshie;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hijikata Yasuki&option=202" target="_blank" rel="nofollow">Hijikata Yasuki;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Soda Yasushi&option=202" target="_blank" rel="nofollow">Soda Yasushi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Inoue Takashi&option=202" target="_blank" rel="nofollow">Inoue Takashi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Okahara Norio&option=202" target="_blank" rel="nofollow">Okahara Norio;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Itoh Toshio&option=202" target="_blank" rel="nofollow">Itoh Toshio;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sasaki Erika&option=202" target="_blank" rel="nofollow">Sasaki Erika;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tojo Arinobu&option=202" target="_blank" rel="nofollow">Tojo Arinobu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Uchimaru Kaoru&option=202" target="_blank" rel="nofollow">Uchimaru Kaoru;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tani Kenzaburo&option=202" target="_blank" rel="nofollow">Tani Kenzaburo;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Project Division of ALA Advanced Medical ResearchThe Institute of Medical ScienceTokyo Japan;</p> <p>Project Division of ALA Advanced Medical ResearchThe Institute of Medical ScienceTokyo Japan;</p> <p>Project Division of ALA Advanced Medical ResearchThe Institute of Medical ScienceTokyo Japan;</p> <p>Project Division of ALA Advanced Medical ResearchThe Institute of Medical ScienceTokyo Japan;</p> <p>Division of Molecular TherapyThe Institute of Medical ScienceTokyo Japan;</p> <p>Department of PathologyThe Institute of Medical ScienceTokyo Japan;</p> <p>Department of PathologyThe Institute of Medical ScienceTokyo Japan;</p> <p>Department of PathologyThe Institute of Medical ScienceTokyo Japan;</p> <p>Department of PathologyThe Institute of Medical ScienceTokyo Japan;</p> <p>Project Division of ALA Advanced Medical ResearchThe Institute of Medical ScienceTokyo Japan;</p> <p>Project Division of ALA Advanced Medical ResearchThe Institute of Medical ScienceTokyo Japan;</p> <p>Project Division of ALA Advanced Medical ResearchThe Institute of Medical ScienceTokyo Japan;</p> <p>Project Division of ALA Advanced Medical ResearchThe Institute of Medical ScienceTokyo Japan;</p> <p>Project Division of ALA Advanced Medical ResearchThe Institute of Medical ScienceTokyo Japan;</p> <p>Central Institute for Experimental AnimalsKawasaki Japan;</p> <p>Central Institute for Experimental AnimalsKawasaki Japan;</p> <p>Central Institute for Experimental AnimalsKawasaki Japan;</p> <p>Central Institute for Experimental AnimalsKawasaki Japan;</p> <p>Division of Molecular TherapyThe Institute of Medical ScienceTokyo Japan;</p> <p>Department of Computational Biology and Medical ScienceThe Tokyo UniversityTokyo Japan;</p> <p>Project Division of ALA Advanced Medical ResearchThe Institute of Medical ScienceTokyo Japan;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/40383.html" title="灵长目">灵长目;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ATLL&option=203" rel="nofollow">ATLL;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=common marmoset&option=203" rel="nofollow">common marmoset;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cyclosporine&option=203" rel="nofollow">cyclosporine;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=HTLV‐1&option=203" rel="nofollow">HTLV‐1;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=MT‐2 cells&option=203" rel="nofollow">MT‐2 cells;</a> </p> <div class="translation"> 机译：ATLL;常见的marmoset;环孢菌素;HTLV-1;MT-2细胞; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025993290.html">A pilot study to establish human T‐cell leukemia virus type 1 (HTLV‐1) carrier model using common marmoset ( <i >Callithrix jacchusCallithrix jacchus )</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hirose Lisa&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hirose Lisa,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hiramoto Takafumi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hiramoto Takafumi,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tian Yamin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Tian Yamin,</a> <a href="/journal-foreign-36449/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of medical primatology .</a> <span>2020</span><span>,第2期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：使用常见的Marmoset建立人T细胞白血病病毒型（HTLV-1）载体模型的试验研究（ callithrix jacchus </ i> callithrix jacchus 的）</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025993013.html">25‐OH‐vitamin D, parathyroid hormone, and calcium serum levels in captive common marmosets ( <i >Callithrix jacchusCallithrix jacchus ): Reference values and effect of age, sex, season, and closure of long bone epiphyses</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bosseler Leslie&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Bosseler Leslie,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bakker Jaco&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Bakker Jaco,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Duchateau Luc&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Duchateau Luc,</a> <a href="/journal-foreign-36449/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of medical primatology .</a> <span>2018</span><span>,第3期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：25-OH-维生素D，甲状旁腺激素和钙血清水平，俘虏常见的MRARMOSETS（ Callithrix Jacchus </ I> Callithrix Jacchus）：年龄，性别，季节和长骨骺端的参考值和效果</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025993066.html">Development and analytical validation of a radioimmunoassay for the quantification of alpha <sub >1</sub>1 ‐proteinase inhibitor in serum and feces from the common marmoset ( <i >Callithrix jacchusCallithrix jacchus )</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Parambeth Joseph Cyrus&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Parambeth Joseph Cyrus,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lidbury Jonathan A.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Lidbury Jonathan A.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Suchodolski Jan S.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Suchodolski Jan S.,</a> <a href="/journal-foreign-36449/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of medical primatology .</a> <span>2018</span><span>,第6期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：血清中血清和粪便中α<sub> 1 </ sub> 1-蛋白酶抑制剂的定量的开发和分析验证（ Callithrix jacchus </ i> Callithrix jacchus）</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-258522_thesis/0705011938974.html">Unusual clinicopathologic findings of chronic colitis associated with anemia, myopathy and steatitis in a common marmoset (Callithrix jacchus)</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Carles Juan-Salles&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Carles Juan-Salles,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Alberto Marco&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Alberto Marco,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xavier Valls&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Xavier Valls </a> <a href="/conference-foreign-258522/" target="_blank" rel="nofollow" class="tuijian_authcolor">Annual Conference of the American Association of Zoo Veterinarians .</a> <span>2000</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：与贫血，患有贫血，肌病和脂肪炎相关的慢性结肠炎的不寻常临床病理发现（Callithrix Jacchus）</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061757453.html">Silencing of FUS in the common marmoset (Callithrix jacchus) brain via stereotaxic injection of an adeno-associated virus encoding shRNA</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Endo Kuniyuki&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Endo Kuniyuki,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=遠藤邦幸&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">遠藤邦幸 </a> <span>2019</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过立体定向注射编码shRNA的腺相关病毒来沉默普通mar猴（Callithrix jacchus）大脑中的FUS</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040002210113.html">Isolation of infectious human T-cell leukemia/lymphotropic virus type III (HTLV-III) from patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) and from healthy carriers: a study of risk groups and tissue sources.</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=S Z Salahuddin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">S Z Salahuddin,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=P D Markham&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">P D Markham,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=M Popovic&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">M Popovic,</a> <span>1985</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：从获得性免疫缺陷综合征（AIDS）或AIDS相关综合症（ARC）患者和健康携带者中分离感染性人类T细胞白血病/ III型淋巴病毒（HTLV-III）：对危险人群和组织来源的研究。</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000132829544.html">Isolation of infectious human T-cell leukemia/lymphotropic virus type III (HTLV-III) from patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) and from healthy carriers: a study of risk groups and tissue sources.</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=S. Z. Salahuddin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">S. Z. Salahuddin,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=P. D. Markham&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">P. D. Markham,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=M. Popovic&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">M. Popovic,</a> <span>1985</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：从获得的免疫缺陷综合征（艾滋病）或艾滋病相关复合物（ARC）和健康携带者的患者中分离感染性人T细胞白血病/淋式病毒III型（HTLV-III）：对风险群体和组织来源的研究。</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201296739184.html">Synchrotron Refraction Enhanced Tomography of an Intact Common Marmoset (iCallithrix jacchus/i)</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Toshihiro Sera&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Toshihiro Sera</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hideo Yokota&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Hideo Yokota</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=SakikoS. Nakamura&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,SakikoS. Nakamura</a> <span> <a href="/journal-cn-56621/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 放射学期刊（英文） </a> </span> <span> . 2011</span><span>,第2期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_foreign-medicine-parasitic-diseases_thesis/0201295301819.html">人T细胞白血病病毒1(HTLV-1)降低粪类圆线虫病患者Th2型免疫反应</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=石星&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 石星</a> <span> <a href="/journal-cn-50340/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 国外医学：寄生虫病分册 </a> </span> <span> . 2002</span><span>,第5期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_medical-recapitulate_thesis/0201253519151.html">嗜人T细胞白血病病毒Ⅰ型(HTLV-Ⅰ)相关性关节炎</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=林星&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 林星</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈平&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陈平</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=郑明英&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,郑明英</a> <span> <a href="/journal-cn-6685/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 医学综述 </a> </span> <span> . 2003</span><span>,第007期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_fudan-university-journal-medical-sciences_thesis/0201250015653.html">皮肤T细胞淋巴瘤患者的人类T淋巴细胞白血病病毒Ⅰ型感染</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=高红阳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 高红阳</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=单易非&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,单易非</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王平&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王平</a> <span> <a href="/journal-cn-6647/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 复旦学报（医学版） </a> </span> <span> . 2002</span><span>,第001期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_natural-science-journal-hainan-university_thesis/0201249386183.html">12例日本人T细胞白血病病毒Ⅰ型相关神经脊髓病矮小患者的分析</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王沙燕&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王沙燕</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=吉田义弘&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,吉田义弘</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=纳光弘&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,纳光弘</a> <span> <a href="/journal-cn-4609/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 海南大学学报（自然科学版） </a> </span> <span> . 2000</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-1923_thesis/02022317360.html">基于无人机着舰的某型舰船运动姿态模型建立及仿真</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=SUN Hai-wen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . SUN Hai-wen</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=孙海文&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,孙海文</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=OUYANG Zhong-hui&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,OUYANG Zhong-hui</a> <span> <a href="/conference-cn-1923/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第四届中国航空兵器大会 </a> <span> <span> . 2015</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020314503228.html">人鼻型NK/T细胞淋巴瘤裸鼠模型的建立及人类表达谱cDNA芯片筛查的研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=何妙侠&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 何妙侠</a> <span> . 2004</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120113418377.html">人T细胞白血病病毒1型(HTLV-1)相关疾病的诊断方法</a> <b>[P]</b> . <span> 中国专利： CN113474358A </span> <span> . 2021-10-01</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120595809.html">一种建立人结外鼻型NK/T细胞淋巴瘤动物模型的方法</a> <b>[P]</b> . <span> 中国专利： CN1879892B </span> <span> . 2010.05.12</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130454865127.html">RIBOZYME OR STABILIZED RIBOZYME NICKING SPECIFIED PART OF HUMAN T-CELL LEUKEMIA VIRUS TYPE-I (HTLV-1), NICKING OF HTLV-I USING THE SAME AND AGENT FOR TREATING HTLV-I-RELATING DISEASE</a> <b>[P]</b> . <span> 外国专利：  JPH10262672A </span> <span> . 1998-10-06</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：人类T细胞白血病病毒（I型）（HTLV-1）的核糖体或稳定的核糖核酸指定部位，使用治疗HTLV-I相关疾病的相同方法和药剂进行HTLV-I的确定 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130455001058.html">Productive of human T-cell leukemia (lymphotropic) retrovirus (HTLV-1) envelope protein fragments in bacteria and use in seroepidemiological studies</a> <b>[P]</b> . <span> 外国专利：  US5674705A </span> <span> . 1997-10-07</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：在细菌中产生人类T细胞白血病（淋巴）逆转录病毒（HTLV-1）包膜蛋白片段，并在血清流行病学研究中使用 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130456658186.html">Production of human T-cell leukemia (lymphotropic) retrovirus (HTLV-I) envelope protein fragments in bacteria and use in seroepidemiological studies</a> <b>[P]</b> . <span> 外国专利：  US5510238A </span> <span> . 1996-04-23</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：在细菌中生产人类T细胞白血病（淋巴）逆转录病毒（HTLV-1）包膜蛋白片段并在血清流行病学研究中使用 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704025993290','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche">  </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)" title="意见反馈">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);" title="回到顶部">回到顶部</a> </li> <li class="shouye"> <a href="/" title="首页">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html" title="关于掌桥">关于掌桥</a></li> <li><a href="/help/helpmap.html" title="资源导航">资源导航</a></li> <li><a href="/help/helpguide.html" title="新手指南">新手指南</a></li> <li><a href="/help/helpcenter.html" title="常见问题">常见问题</a></li> <li><a href="/sitemap.html" title="网站地图">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9" title="版权声明">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank" title="ICP备案号">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704025993290down" data-source="7," data-out-id="06xA4Hpv5oMIyKVzlCb1DmJ7DJJegRjU1RAlof3DjNrR4I0FtyrjfpWy/RD6G9xT," data-f-source-id="7" data-title="A pilot study to establish human T‐cell leukemia virus type 1 (HTLV‐1) carrier model using common marmoset ( <i >Callithrix jacchusCallithrix jacchus )" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="36449" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="A pilot study to establish human T‐cell leukemia virus type 1 (HTLV‐1) carrier model using common marmoset ( <i >Callithrix jacchusCallithrix jacchus )"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/newmail.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.7.8"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/sse.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.7.8"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>

A pilot study to establish human T‐cell leukemia virus type 1 (HTLV‐1) carrier model using common marmoset ( Callithrix jacchusCallithrix jacchus )

摘要