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首页> 外文期刊>Journal of medical primatology >Determination of major histocompatibility class I and class II genetic composition of the Caribbean Primate Center specific pathogen‐free rhesus macaque ( Macaca mulattaMacaca mulatta ) colony based on massively parallel sequencing
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Determination of major histocompatibility class I and class II genetic composition of the Caribbean Primate Center specific pathogen‐free rhesus macaque ( Macaca mulattaMacaca mulatta ) colony based on massively parallel sequencing

机译：基于大规模平行测序，Caribbean Gimory Cents的主要组织相容性I类和II类遗传成分的测定基于大规模平行测序的基于大规模平行测序

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Abstract <section numbered="no" xml:id="jmp12353-sec-0001"> <title type="main">Background > Knowledge of major histocompatibility complex ( <fc>MHC</fc> ) composition and distribution in rhesus macaque colonies is critical for management strategies that maximize the utility of this model for biomedical research. </section> <section numbered="no" xml:id="jmp12353-sec-0002"> <title type="main">Methods > Variation within the Mamu‐A and Mamu‐B (class I) and <fc>DRB</fc> , <fc>DQA</fc> /B, and <fc>DPA</fc> /B (class <fc>II</fc> ) regions of 379 animals from the Caribbean Primate Research Center's (CPRC) specific pathogen free ( <fc>SPF</fc> ) colony was examined using massively parallel sequencing. </section> <section numbered="no" xml:id="jmp12353-sec-0003"> <title type="main">Results > Analyses of the 7 <fc>MHC</fc> loci revealed a background of Indian origin with high levels of variation despite past genetic bottlenecks. All loci exhibited mutual linkage disequilibria while conforming to Hardy–Weinberg expectations suggesting the achievement of mutation‐selection balance. </section> <section numbered="no" xml:id="jmp12353-sec-0004"> <title type="main">Conclusion > The CPRC's <fc>SPF</fc> colony is a significant resource for research on <fc>AIDS</fc> a </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：ID =“JMP12353-ABS-ABS-0001”XML：Lang =“en”> <标题类型=“main”>抽象</ title> <secto numbyed =“no”xml：id = “JMP12353-SEC-0001”> <标题类型=“main”>背景</标题> >主要组织相容性复合物的知识（<FC> MHC </ FC>）组成和恒星猕猴的分布对于管理至关重要最大化该模型为生物医学研究的效用的策略。 </ p> </ section> <secto numbyed =“no”xml：id =“jmp12353-sec-0002”> <title类型=“main”>方法</ title> >在 mamu内的变化-a </ i>和 mamu-b </ i>（I类）和 <fc> drb </ fc> </ i>， <fc> dqa </ fc> /来自加勒比灵长类动物研究中心（CPRC）特定病原体的379只动物的B，</ i>和 <Ⅰ型>（类<FC> II </ FC>）（类别<FC> II </ FC>）区域使用大规模平行测序检查Free（<FC> SPF </ FC>）菌落。 </ p> </ section> <secto numbyed =“no”xml：id =“jmp12353-sec-0003”> <标题类型=“main”>结果</ title> >分析7 <fc> MHC </ FC> LOCI尽管过去的遗传瓶颈，但仍然透露了印度起源的背景，尽管过去的遗传瓶颈。所有基因座在符合Hardy-Weinberg期望的同时表现出相互联系的不平衡，表明突变选择余额的实现。 </ p> </ section> <部分编号=“否”XML：ID =“JMP12353-SEC-0004”> <标题类型=“main”>结论</ title> > CPRC的<FC> SPF < / FC>殖民地是对<FC>艾滋病研究的重要资源</ FC> a </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-36449/'>《Journal of medical primatology》</a> <b style="margin: 0 2px;">|</b><span>2018年第6期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kanthaswamy Sreetharan&option=202" target="_blank" rel="nofollow">Kanthaswamy Sreetharan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Oldt Robert F.&option=202" target="_blank" rel="nofollow">Oldt Robert F.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ng Jillian&option=202" target="_blank" rel="nofollow">Ng Jillian;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Smith David Glenn&option=202" target="_blank" rel="nofollow">Smith David Glenn;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Martínez Melween I.&option=202" target="_blank" rel="nofollow">Martínez Melween I.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sariol Carlos A.&option=202" target="_blank" rel="nofollow">Sariol Carlos A.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>California National Primate Research CenterUniversity of CaliforniaDavis CA USA;</p> <p>School of Mathematics and Natural SciencesArizona State University (ASU) at the West CampusGlendale AZ USA;</p> <p>California National Primate Research CenterUniversity of CaliforniaDavis CA USA;</p> <p>California National Primate Research CenterUniversity of CaliforniaDavis CA USA;</p> <p>Caribbean Primate Research CenterUniversity of Puerto Rico‐Medical Sciences CampusSan Juan Puerto Rico;</p> <p>Caribbean Primate Research CenterUniversity of Puerto Rico‐Medical Sciences CampusSan Juan Puerto Rico;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/40383.html" title="灵长目">灵长目;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=colony genetic structure&option=203" rel="nofollow">colony genetic structure;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=genetic management&option=203" rel="nofollow">genetic management;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=major histocompatibility complex genotyping&option=203" rel="nofollow">major histocompatibility complex genotyping;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mamu haplotypes&option=203" rel="nofollow">Mamu haplotypes;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=next generation sequence&option=203" rel="nofollow">next generation sequence;</a> </p> <div class="translation"> 机译：殖民地遗传结构;遗传管理;主要组织相容性复杂基因分型;Mamu单倍型;下一代序列; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025993271.html">Determination of major histocompatibility class I and class II genetic composition of the Caribbean Primate Center specific pathogen‐free rhesus macaque ( <i >Macaca mulattaMacaca mulatta ) colony based on massively parallel 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