Is genetic drift to blame for testicular dysgenesis syndrome in Semliki chimpanzees (        <i >Pan troglodytes schweinfurthiiPan troglodytes schweinfurthii        )?

Rich Alicia M.; Wasserman Michael D.; Deimel Caroline; Breeden Scott K.; Kaestle Frederika; Hunt Kevin D.

摘要

Abstract <section numbered="no" xml:id="jmp12352-sec-0001"> <title type="main">Background > We present 3 likely cases of testicular dysgenesis syndrome (TDS) within a community of chimpanzees ( Pan troglodytes schweinfurthii ). We tested whether genetic drift may be the culprit, as a genetic cause has been suspected to account for TDS among other wildlife. </section> <section numbered="no" xml:id="jmp12352-sec-0002"> <title type="main">Methods >We successfully sequenced a 367‐bp segment spanning the first hypervariable region within the D‐loop of the mitochondrial genome for 78 DNA samples. </section> <section numbered="no" xml:id="jmp12352-sec-0003"> <title type="main">Results > We found 24 polymorphic sequence sites consisting of 7 singletons and 17 parsimony informative sites. This sample contained 9 haplotypes with a diversity index of 0.78 (SD?=?0.03). All tests against the null hypothesis of neutral polymorphisms were non‐significant ( P ??.10). The mismatch distribution of pairwise differences does not fit a Poisson's curve (raggedness index?=?0.166; SSD?=?0.12; P ?=?1). </section> <section numbered="no" xml:id="jmp12352-sec-0004"> <title type="main">Conclusions >Thus, we found no significant signs of genetic isolation, population expansion, or genetic bottleneck. Alternative causes of TDS and how they might pertain to this population are discussed. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：ID =“JMP12352-ABS-ABS-0001”XML：lang =“en”> <标题类型=“main”>抽象</ title> <sectouned =“no”xml：id = “JMP12352-SEC-0001”> <标题类型=“main”>背景</ title> >我们在黑猩猩（ PAN Troglodytes Schweinfurthii）中存在3个可能的睾丸性妊娠综合征（TDS）的情况I>）。我们测试了遗传漂移是否可能是罪魁祸首，因为遗传原因已怀疑涉及其他野生动物中的TDS。 </ p> </ section> <secto numbyed =“no”xml：id =“jmp12352-sec-0002”> <标题类型=“main”>方法</ title> >我们成功测序了367-bp培养在线粒体基因组的D-环中的第一个超变性区域的段为78个DNA样本。</ p> </段> <截面编号=“否”XML：ID =“JMP12352-SEC-0003”> <标题类型=“main”>结果</ title> >我们发现24个多态性序列站点，由7个单身和17个定义信息网站组成。该样品含有9个单倍型，分集指数为0.78（SD？= 0.03）。针对空档多态性的零假设的所有测试都是非显着的（ P </ i>？＆？10）。成对差异的不匹配分布不适合泊松曲线（粗糙索引？=？0.166; SSD？=？0.12; P </ i>？=？1）。 </ p> </段> <部分编号=“否”XML：ID =“JMP12352-SEC-0004”> <标题类型=“main”>结论</标题> >因此，我们发现没有有重大迹象遗传分离，人口扩张或遗传瓶颈。讨论了TDS的替代原因以及它们如何涉及到该群体。</ p> </段> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-36449/'>《Journal of medical primatology》</a> <b style="margin: 0 2px;">|</b><span>2018年第4期</span><b style="margin: 0 2px;">|</b><span>共13页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rich Alicia M.&option=202" target="_blank" rel="nofollow">Rich Alicia M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wasserman Michael D.&option=202" target="_blank" rel="nofollow">Wasserman Michael D.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Deimel Caroline&option=202" target="_blank" rel="nofollow">Deimel Caroline;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Breeden Scott K.&option=202" target="_blank" rel="nofollow">Breeden Scott K.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kaestle Frederika&option=202" target="_blank" rel="nofollow">Kaestle Frederika;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hunt Kevin D.&option=202" target="_blank" rel="nofollow">Hunt Kevin D.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of AnthropologyBoston UniversityBoston MA USA;</p> <p>Department of AnthropologyIndiana UniversityBloomington IN USA;</p> <p>Department of AnthropologyIndiana UniversityBloomington IN USA;</p> <p>Marian University College of Osteopathic MedicineIndianapolis IN USA;</p> <p>Department of AnthropologyIndiana UniversityBloomington IN USA;</p> <p>Department of AnthropologyIndiana UniversityBloomington IN USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/40383.html" title="灵长目">灵长目;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cryptorchidism&option=203" rel="nofollow">cryptorchidism;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=demography&option=203" rel="nofollow">demography;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=fertility&option=203" rel="nofollow">fertility;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=mt DNA&option=203" rel="nofollow">mt DNA;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=testicular hydrocele&option=203" rel="nofollow">testicular hydrocele;</a> </p> <div class="translation"> 机译：密码刺激;人口统计学;生育;MT DNA;睾丸氢核; 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Is genetic drift to blame for testicular dysgenesis syndrome in Semliki chimpanzees ( Pan troglodytes schweinfurthiiPan troglodytes schweinfurthii )?

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