A simultaneous oral and intramuscular prime/sublingual boost with a DNA/Modified Vaccinia Ankara viral vector‐based vaccine induces simian immunodeficiency virus‐specific systemic and mucosal immune responses in juvenile rhesus macaques

Curtis Alan D.; Jensen Kara; Van Rompay Koen K. A.; Amara Rama R.; Kozlowski Pamela A.; De Paris Kristina

摘要

Abstract <section numbered="no" xml:id="jmp12372-sec-0001"> <title type="main">Background >A pediatric vaccine to prevent breast milk transmission of human immunodeficiency virus (HIV) may generate greater immune responses at viral entry sites if given by an oral route. </section> <section numbered="no" xml:id="jmp12372-sec-0002"> <title type="main">Methods >We compared immune responses induced in juvenile macaques by prime/boosting with simian immunodeficiency virus (SIV)‐expressing DNA/modified vaccinia Ankara virus (MVA) by the intramuscular route (IM), the oral (O)/tonsillar routes (T), the O/sublingual (SL) routes, and O+IM/SL routes. </section> <section numbered="no" xml:id="jmp12372-sec-0003"> <title type="main">Results > O/T or O/SL immunization generated SIV‐specific T cells in mucosal tissues but failed to induce SIV‐specific IgA in saliva or stool or IgG in plasma. IM/IM or O+IM/SL generated humoral and cellular responses to SIV. IM/IM generated greater frequencies of T <sub>FH</sub> in spleen, but O+IM/SL animals had higher avidity plasma IgG and more often demonstrated mucosal IgA responses. </section> <section numbered="no" xml:id="jmp12372-sec-0004"> <title type="main">Conclusion >These results suggest that codelivery of HIV DNA/MVA vaccines by the oral and IM routes might be optimal for generating both systemic and mucosal antibodies. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：ID =“JMP12372-ABS-ABS-ABS-0001”> <标题类型=“MAIN”> Abstract </ title> <secto numbyed =“No”XML：ID =“JMP12372-SEC-0001” > <标题类型=“main”>背景</标题> >预防人类免疫缺陷病毒（HIV）的儿科疫苗可以在病毒进入位点产生更大的免疫应答，如果给药，则在口腔途径给出。</ p> </段> <部分编号=“否”XML：ID =“JMP12372-SEC-0002”> <标题类型=“main”>方法</标题> >我们比较了在少年猕猴中诱导的免疫应答用肌肉途径（IM），口腔（O）/扁桃体路线（T），O /舌头（SL）路线，用猿猴免疫缺陷病毒（SIV） - 表达DNA /修饰的痘苗病毒ankara病毒（MVA），和o + im / sl路由。</ p> </ section> <secteneded =“no”xml：id =“jmp12372-sec-0003”> <标题类型=“main”>结果</ title> > O / T或O / SL免疫产生SIV - 特异性T细胞在粘膜组织中，但未能在唾液或粪便中诱导SIV特异性IgA或血浆中的IgG。 IM / IM或O + IM / SL为SIV产生了体液和细胞响应。 IM / IM在脾脏中产生的频率为T <sub> FH </ sub>，但是o + IM / SL动物具有更高的亲和力等离子体IgG，并且更常见的是粘膜IgA反应。 </ p> </段> <部分编号=“否”xml：id =“jmp12372-sec-0004”> <标题类型=“main”>结论</ title> >这些结果表明艾滋病毒的编码递送口腔和IM途径的DNA / MVA疫苗可能是最佳的，用于产生全身和粘膜抗体。</ p> </段> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-36449/'>《Journal of medical primatology》</a> <b style="margin: 0 2px;">|</b><span>2018年第5期</span><b style="margin: 0 2px;">|</b><span>共10页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Curtis Alan D.&option=202" target="_blank" rel="nofollow">Curtis Alan D.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jensen Kara&option=202" target="_blank" rel="nofollow">Jensen Kara;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Van Rompay Koen K. A.&option=202" target="_blank" rel="nofollow">Van Rompay Koen K. A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Amara Rama R.&option=202" target="_blank" rel="nofollow">Amara Rama R.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kozlowski Pamela A.&option=202" target="_blank" rel="nofollow">Kozlowski Pamela A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=De Paris Kristina&option=202" target="_blank" rel="nofollow">De Paris Kristina;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Microbiology and ImmunologyUniversity of North Carolina at Chapel HillChapel Hill North Carolina;</p> <p>Department of Microbiology and ImmunologyUniversity of North Carolina at Chapel HillChapel Hill North Carolina;</p> <p>California National Primate Research CenterUniversity of CaliforniaDavis California;</p> <p>Yerkes National Primate Research CenterEmory UniversityAtlanta Georgia;</p> <p>Department of Microbiology Immunology and ParasitologyLouisiana State University Health Sciences CenterNew Orleans Louisiana;</p> <p>Department of Microbiology and ImmunologyUniversity of North Carolina at Chapel HillChapel Hill North Carolina;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/40383.html" title="灵长目">灵长目;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=HIV&option=203" rel="nofollow">HIV;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=oral route&option=203" rel="nofollow">oral route;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=pediatric vaccine&option=203" rel="nofollow">pediatric vaccine;</a> </p> <div class="translation"> 机译：艾滋病毒;口腔途径;儿科疫苗; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025993237.html">A simultaneous oral and intramuscular prime/sublingual boost with a DNA/Modified Vaccinia Ankara viral vector‐based vaccine induces simian immunodeficiency virus‐specific systemic and mucosal immune responses in juvenile rhesus macaques</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Curtis Alan D.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Curtis Alan D.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jensen Kara&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jensen Kara,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Van Rompay Koen K. 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href="/academic-journal-cn_chinese-journal-immunology_thesis/0201223474691.html">Chitosan-DNA基因免疫诱导粘膜特异性免疫应答及其抗CVB3感染作用</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=徐薇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 徐薇</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=沈燕&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,沈燕</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王立新&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王立新</a> <span> <a href="/journal-cn-5793/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国免疫学杂志 </a> </span> <span> . 2003</span><span>,第012期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-31594_thesis/02022384423.html">HIV-1 DNA疫苗初始免疫联合重组痘苗病毒或病毒样颗粒疫苗加强免疫诱导的小鼠特异性细胞和体液免疫反应</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈磊&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陈磊</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张欣&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张欣</a> <span> <a href="/conference-cn-31594/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第一届中国艾滋病性病防治大会 </a> <span> <span> . 2001</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020314916896.html">pcDNA3.1/HSP70-MAGE-3融合DNA疫苗诱导特异性抗肿瘤免疫应答的实验研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘杏娥&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 刘杏娥</a> <span> . 2004</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06130425652904.html">Methods for inducing an immune response in a host comprising administering modified vaccinia virus ankara (MVA) recombinants comprising human immunodeficiency virus (HIV) genes inserted into one or more intergenic regions (IGRs)</a> <b>[P]</b> . <span> 外国专利：  US8021669B2 </span> <span> . 2011-09-20</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：在宿主中诱导免疫应答的方法，包括施用经修饰的牛痘病毒安卡拉（MVA）重组体，该重组体包含插入一个或多个基因间区域（IGR）的人免疫缺陷病毒（HIV）基因 </span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06130457528230.html">DNA STRUCTURES CONTAINING NUCLEIC ACIDS ENCODING HUMAN INFLUENZAL VIRUSES, POLYNUCLEOTIDE VACCINE CONTAINING DNA STRUCTURES INDUCING THE FORMATION OF NEUTRALIZING ANTIBODIES AND SPECIFIC CYTOSTATIC T-LYMPHOCYTES, EXPRESSION VECTORS, PROTECTION METHOD FROM INFLUENZAL VIRUS INFECTION AND THE USE OF THE VIRUSES AND GENES THEREOF FOR INDUCING IN VIVO IMMUNE RESPONSE</a> <b>[P]</b> . <span> 外国专利：  CZ9502373A3 </span> <span> . 1996-02-14</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：包含编码人类流感病毒的核酸的DNA结构，包含核酸结构的多核苷酸疫苗，诱导中和抗体和特定的细胞周期T淋巴细胞的中性抗原和表达的病毒，细菌的表达免疫反应 </span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130457535711.html">DNA STRUCTURES CONTAINING NUCLEIC ACIDS ENCODING HUMAN INFLUENZAL VIRUSES, POLYNUCLEOTIDE VACCINE CONTAINING DNA STRUCTURES INDUCING THE FORMATION OF NEUTRALIZING ANTIBODIES AND SPECIFIC CYTOSTATIC T-LYMPHOCYTES, EXPRESSION VECTORS, PROTECTION METHOD FROM INFLUENZAL VIRUS INFECTION AND THE USE OF THE VIRUSES AND GENES THEREOF FOR INDUCING IN VIVO IMMUNE RESPONSE</a> <b>[P]</b> . <span> 外国专利：  CZ237395A3 </span> <span> . 1996-02-14</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：包含编码人类流感病毒的核酸的DNA结构，包含核酸结构的多核苷酸疫苗，诱导中和抗体和特定的细胞周期T淋巴细胞的中性抗原和表达的病毒，细菌的表达免疫反应 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704025993237','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p 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