Reported analgesic and anaesthetic administration to non‐human primates undergoing experimental surgical procedure: 2010‐2015

Bertrand Henri Georges Michel Justin; Sandersen Charlotte; Flecknell Paul Andrew

摘要

Abstract <section numbered="no" xml:id="jmp12346-sec-0001"> <title type="main">Background >The use of non‐human primates (NHPs) in research remains a major societal concern with public expectations that appropriate anaesthetics and analgesics are used to minimize any pain or distress caused to animals undergoing invasive procedures. A literature review was conducted to examine the reporting of anaesthesia and analgesia methods used in non‐human primates undergoing surgical procedures, with recovery from anaesthesia. </section> <section numbered="no" xml:id="jmp12346-sec-0002"> <title type="main">Methods >A total of 397 papers from peer‐review journals published between 2010 and 2015 were examined. </section> <section numbered="no" xml:id="jmp12346-sec-0003"> <title type="main">Results >Only 25.9% of papers reported the analgesic regimen used, with carprofen and buprenorphine the 2 most widely used agents. Reporting of the anaesthetic regimens was included in 49.9% of papers. Ketamine and isoflurane were the most frequently used anaesthetic agents. </section> <section numbered="no" xml:id="jmp12346-sec-0004"> <title type="main">Conclusions >Anaesthetic and analgesic regimens administered to NHPs remain poorly reported. This lack of detailed descriptions of protocols does little to reassure the public or regulatory authorities that appropriate high standards of perioperative care are employed. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：ID =“JMP12346-ABS-0001”XML：Lang =“en”> <标题类型=“main”>抽象</ title> <secueeded =“no”xml：id = “JMP12346-SEC-0001”> <标题类型=“Main”>背景</标题> >在研究中使用非人类灵长类动物（NHPS）仍然是具有适当麻醉和镇痛药的公共期望的主要社会问题用于尽量减少对受侵入手术的动物造成的任何疼痛或痛苦。进行了文献综述，以检查在接受外科手术的非人印象中使用的麻醉和镇痛方法的报告，从麻醉中恢复。</ p> </段> <部分编号=“否”XML：ID =“JMP12346 -sec-0002“> <标题类型=”main“>方法</ title> >在2010年至2015年之间发布的同伴审查期刊总共397篇论文进行了检查。</ p> </ section> <section numbered =“否”XML：ID =“JMP12346-SEC-0003”> <标题类型=“main”>结果</标题> >仅25.9％的论文报告使用镇痛的方案，用储物索和丁丙诺啡2最广泛使用的代理商。报告麻醉方案包含在49.9％的论文中。氯胺酮和异氟醚是最常用的麻醉剂。</ p> </ section> <secteneded =“no”xml：id =“jmp12346-sec-0004”> <标题类型=“main”>结论</ title >施用于NHP的麻醉剂和镇痛药物仍然报告差。这种缺乏对协议的详细描述对公众或监管当局来说几乎没有，以便使用适当的高标准的围手术化护理。</ p> </段> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-36449/'>《Journal of medical primatology》</a> <b style="margin: 0 2px;">|</b><span>2018年第4期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bertrand Henri Georges Michel Justin&option=202" target="_blank" rel="nofollow">Bertrand Henri Georges Michel Justin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sandersen Charlotte&option=202" target="_blank" rel="nofollow">Sandersen Charlotte;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Flecknell Paul Andrew&option=202" target="_blank" rel="nofollow">Flecknell Paul Andrew;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Biomedical ServicesUniversity of OxfordOxford UK;</p> <p>Veterinary Anesthesia DepartmentUniversity of LiegeLiege Belgium;</p> <p>Comparative Biology CentreNewcastle UniversityNewcastle Upon Tyne UK;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/40383.html" title="灵长目">灵长目;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=anaesthesia&option=203" rel="nofollow">anaesthesia;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=analgesia&option=203" rel="nofollow">analgesia;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=macaque&option=203" rel="nofollow">macaque;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=primate&option=203" rel="nofollow">primate;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=surgery&option=203" rel="nofollow">surgery;</a> </p> <div class="translation"> 机译：麻醉;镇痛;猕猴;灵长类动物;手术; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025992941.html">Reported analgesic and anaesthetic administration to non‐human primates undergoing experimental surgical procedure: 2010‐2015</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bertrand Henri Georges Michel Justin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Bertrand Henri Georges Michel Justin,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sandersen 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href="/patent-detail/06120103182143.html">用于进行麻醉或镇痛镇静的设备以及操作用于进行麻醉或镇痛镇静的设备的方法</a> <b>[P]</b> . <span> 中国专利： CN104302342A </span> <span> . 2015-01-21</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120111145489.html">一种实验动物麻醉镇痛用中药制剂及其制备方法</a> <b>[P]</b> . <span> 中国专利： CN108653493A </span> <span> . 2018-10-16</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130412222519.html">use of ibuprofen to reduce pain in human patients undergoing surgery, use of ibuprofen to reduce surgical pain in human patients and use of ibuprofen to improve outpatient time after operation in human patients who undergo orthopedic surgical procedures</a> <b>[P]</b> . <span> 外国专利：  BRPI1006222A2 </span> <span> . 2016-08-02</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：使用布洛芬减轻手术患者的疼痛，使用布洛芬减轻手术患者的疼痛以及使用布洛芬改善整形外科手术患者的门诊时间 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130424794380.html">Method for generating images of a human body zone undergoing a surgical operation by means of an apparatus for minimally invasive surgical procedures</a> <b>[P]</b> . <span> 外国专利：  EP2277441A1 </span> <span> . 2011-01-26</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：借助于用于微创外科手术的设备产生进行外科手术的人体区域的图像的方法 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130492400256.html">Apparatus for the administration of analgesics and anaesthetics</a> <b>[P]</b> . <span> 外国专利：  US2720203A </span> <span> . 1955-10-11</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: 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