Effects of MetAP2 inhibition on hyperphagia and body weight in Prader-Willi syndrome: A randomized, double-blind, placebo-controlled trial

McCandless Shawn E.; Yanovski Jack A.; Miller Jennifer; Fu Cary; Bird Lynne M.; Salehi Parisa; Chan Christine L.; Stafford Diane; Abuzzahab M. Jennifer; Viskochil David; Barlow Sarah E.; Angulo Moris; Myers Susan E.; Whitman Barbara Y.; Styne Dennis; Roof Elizabeth; Dykens Elisabeth M.; Scheimann Ann O.; Malloy Jaret; Zhuang Dongliang; Taylor Kristin; Hughes Thomas E.; Kim Dennis D.; Butler Merlin G.

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Effects of MetAP2 inhibition on hyperphagia and body weight in Prader-Willi syndrome: A randomized, double-blind, placebo-controlled trial

机译：Metap2抑制对Prader-Willi综合征的倍瘫和体重的影响：随机，双盲，安慰剂对照试验

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Aims: There are no treatments for the extreme hyperphagia and obesity in Prader-Willi syndrome (PWS). The bestPWS clinical trial assessed the efficacy, safety and tolerability of the methionine aminopeptidase 2 (MetAP2) inhibitor, beloranib.

机译：目的：PRADER-WILLI综合征（PWS）中没有治疗极端褐斑和肥胖症。 eSTPWS临床试验评估了蛋氨酸氨基肽酶2（Metap2）抑制剂，Beloranib的功效，安全性和耐受性。

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来源
《Diabetes, obesity & metabolism》 |2017年第12期|共11页
作者
McCandless Shawn E.; Yanovski Jack A.; Miller Jennifer; Fu Cary; Bird Lynne M.; Salehi Parisa; Chan Christine L.; Stafford Diane; Abuzzahab M. Jennifer; Viskochil David; Barlow Sarah E.; Angulo Moris; Myers Susan E.; Whitman Barbara Y.; Styne Dennis; Roof Elizabeth; Dykens Elisabeth M.; Scheimann Ann O.; Malloy Jaret; Zhuang Dongliang; Taylor Kristin; Hughes Thomas E.; Kim Dennis D.; Butler Merlin G.;
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作者单位

UH Cleveland Med Ctr Cleveland OH USA;

Eunice Kennedy Shriver Natl Inst Child Hlth &

Hum Sect Growth &

Obes Div Intramural Res NIH;

Univ Florida Gainesville FL USA;

Vanderbilt Univ Med Ctr Nashville TN USA;

UCSD Rady Childrens Hosp San Diego CA USA;

Seattle Childrens Hosp Div Endocrinol &

Diabet Seattle WA USA;

Childrens Hosp Colorado Aurora CO USA;

Childrens Hosp Boston Boston MA USA;

Childrens Hosp &

Clin Minnesota St Paul MN USA;

Univ Utah Salt Lake City UT USA;

Baylor Coll Med Houston TX 77030 USA;

Winthrop Univ Hosp Mineola NY 11501 USA;

St Louis Univ Sch Med St Louis MO USA;

St Louis Univ Sch Med St Louis MO USA;

UC Davis Childrens Hosp UC Davis Med Ctr Davis CA USA;

Vanderbilt Univ Med Ctr Nashville TN USA;

Vanderbilt Univ Med Ctr Nashville TN USA;

Baylor Coll Med Baltimore MD USA;

Zafgen Inc 175 Portland St 4th Floor Boston MA 02114 USA;

Zafgen Inc 175 Portland St 4th Floor Boston MA 02114 USA;

Zafgen Inc 175 Portland St 4th Floor Boston MA 02114 USA;

Zafgen Inc 175 Portland St 4th Floor Boston MA 02114 USA;

Zafgen Inc 175 Portland St 4th Floor Boston MA 02114 USA;

Univ Kansas Med Ctr Dept Psychiat Kansas City KS 66103 USA;

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原文格式 PDF
正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词
antiobesity drug; appetite control; clinical trial; phase III study; randomized trial;

机译：抗菌药;食欲控制;临床试验;第三阶段研究;随机试验;

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1. Effects of MetAP2 inhibition on hyperphagia and body weight in Prader-Willi syndrome: A randomized, double-blind, placebo-controlled trial [J] . McCandless Shawn E., Yanovski Jack A., Miller Jennifer, Diabetes, obesity & metabolism . 2017,第12期

机译：Metap2抑制对Prader-Willi综合征的倍瘫和体重的影响：随机，双盲，安慰剂对照试验
2. Effects of oral -lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial [J] . Li Nong, Yan Weili, Hu Xiaojuan, Clinical Endocrinology . 2017,第5期

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3. Effects of spirulina consumption on body weight, blood pressure, and endothelial function in overweight hypertensive Caucasians: a double-blind, placebo-controlled, randomized trial [J] . Miczke A., Szulinska M., Hansdorfer-Korzon R., European review for medical and pharmacological sciences. . 2016,第1期

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6. Effects of MetAP2 inhibition on hyperphagia and body weight in Prader-Willi syndrome: a randomized double-blind placebo-controlled trial [O] . Shawn E. McCandless, Jack A. Yanovski, Jennifer Miller, -1

机译：MetAP2抑制对Prader-Willi综合征食欲亢进和体重的影响：一项随机双盲安慰剂对照试验
7. Expression of concern: Comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial and The effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial [O] . 2020

机译：令人担忧的表达：肌醇和二甲双胍对多囊卵巢综合征妇女精神健康参数和氧化胁迫的生物标志物的比较：随机，双盲，安慰剂对照试验和鱼油ω-3脂肪酸补充的影响对多囊卵巢综合征患者的心理健康参数和代谢状态：随机，双盲，安慰剂对照试验

Effects of MetAP2 inhibition on hyperphagia and body weight in Prader-Willi syndrome: A randomized, double-blind, placebo-controlled trial

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