Postprandial renal haemodynamic effect of lixisenatide vs once-daily insulin-glulisine in patients with type 2 diabetes on insulin-glargine: An 8-week, randomised, open-label trial

Tonneijck Lennart; Muskiet Marcel H. A.; Smits Mark M.; Hoekstra Trynke; Kramer Mark H. H.; Danser A. H. Jan; Diamant Michaela; Joles Jaap A.; van Raalte Daniel H.

首页> 外文期刊>Diabetes, obesity & metabolism >Postprandial renal haemodynamic effect of lixisenatide vs once-daily insulin-glulisine in patients with type 2 diabetes on insulin-glargine: An 8-week, randomised, open-label trial

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Postprandial renal haemodynamic effect of lixisenatide vs once-daily insulin-glulisine in patients with type 2 diabetes on insulin-glargine: An 8-week, randomised, open-label trial

机译：Lixisenatide的餐后肾脏血液动力学效果对2型胰岛素糖尿病患者持续的胰岛素 - 青春尿苷：8周，随机开放标签试验

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Aim: To determine whether lixisenatide, a prandial short-acting glucagon-like peptide receptor agonist (GLP-1RA), ameliorates postprandial glomerular hyperfiltration in patients with type 2 diabetes mellitus (T2DM) compared with insulin-glulisine (iGlu).

机译：目的：为了确定LixIsenatide是否是糖尿病患者（GLP-1RA）的解索肽，一种肾小球类肽受体激动剂（GLP-1RA），与胰岛素 - 青少年（Iglu）相比，患有2型糖尿病（T2DM）的患者的餐后肾小球高滤育。

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来源
《Diabetes, obesity & metabolism》 |2017年第12期|共12页
作者
Tonneijck Lennart; Muskiet Marcel H. A.; Smits Mark M.; Hoekstra Trynke; Kramer Mark H. H.; Danser A. H. Jan; Diamant Michaela; Joles Jaap A.; van Raalte Daniel H.;
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作者单位

Vrije Univ Amsterdam Dept Internal Med Diabet Ctr Med Ctr Amsterdam Netherlands;

Vrije Univ Amsterdam Dept Internal Med Diabet Ctr Med Ctr Amsterdam Netherlands;

Vrije Univ Amsterdam Dept Internal Med Diabet Ctr Med Ctr Amsterdam Netherlands;

Vrije Univ Amsterdam Dept Hlth Sci Amsterdam Netherlands;

Vrije Univ Amsterdam Dept Internal Med Diabet Ctr Med Ctr Amsterdam Netherlands;

Erasmus Univ Div Pharmacol &

Vasc Med Dept Internal Med Med Ctr Rotterdam Netherlands;

Vrije Univ Amsterdam Dept Internal Med Diabet Ctr Med Ctr Amsterdam Netherlands;

Univ Med Ctr Dept Hypertens &

Nephrol Utrecht Netherlands;

Vrije Univ Amsterdam Dept Internal Med Diabet Ctr Med Ctr Amsterdam Netherlands;

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正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词
diabetes; glomerular filtration rate; glomerular hyperfiltration; glomerular pressure; GLP-1 receptor agonist; glucagon-like peptide-1; insulin-glulisine; lixisenatide; natriuresis; renal function; renal haemodynamics; type 2 diabetes;

机译：糖尿病;肾小球过滤速率;肾小球超滤;肾小球压力;GLP-1受体激动剂;胰胰高血糖素样肽-1;胰岛素 - 青毒素;Lixisenatide;Natriures;肾功能;肾功能;肾脏血液动力学;2型糖尿病;2型糖尿病;

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1. Postprandial renal haemodynamic effect of lixisenatide vs once-daily insulin-glulisine in patients with type 2 diabetes on insulin-glargine: An 8-week, randomised, open-label trial [J] . Tonneijck Lennart, Muskiet Marcel H. A., Smits Mark M., Diabetes, obesity & metabolism . 2017,第12期

机译：Lixisenatide的餐后肾脏血液动力学效果对2型胰岛素糖尿病患者持续的胰岛素 - 青春尿苷：8周，随机开放标签试验
2. Contrasting Effects of Lixisenatide and Liraglutide on Postprandial Glycemic Control, Gastric Emptying, and Safety Parameters in Patients With Type 2 Diabetes on Optimized Insulin Glargine With or Without Metformin: A Randomized, Open-Label Trial [J] . Meier Juris J., Rosenstock Julio, Hincelin-Mery Agnes, Diabetes care . 2015,第7期

机译：Lixisenatide和Liraglutide对2型糖尿病患者治疗胰腺炎患者后糖尿病的对比作用，有或没有二甲双胍：随机，开放标签试验
3. Comparison of thrice-daily premixed insulin (insulin lispro premix) with basal-bolus (insulin glargine once-daily plus thrice-daily prandial insulin lispro) therapy in east Asian patients with type 2 diabetes insufficiently controlled with twice-daily premixed insulin: an open-label, randomised, controlled trial [J] . Jia Weiping, Xiao Xinhua, Ji Qiuhe, The lancet. Diabetes & endocrinology. . 2015,第4期

机译：东亚2型糖尿病患者每日两次三次预混胰岛素（赖脯胰岛素预混物）与基底推注（甘精胰岛素每天一次加三餐膳食赖脯胰岛素）的比较，每日两次预混胰岛素不能充分控制：标签，随机，对照试验
4. Identification of intra-patient variability in the postprandial response of patients with type 1 diabetes [C] . Alejandro J. Laguna, Paolo Rossetti, F. Javier Ampudia-Blasco, IFAC Symposium on Biological and Medical Systems . 2012

机译：鉴定患有1型糖尿病患者的后催乳剂中的患者内变异性
5. A randomized, open-label, intervention study to evaluate the effect of diet composition on weight gain in obese, type 2 diabetes patients receiving intensive insulin therapy. [D] . Villareal, Roland. 2008

机译：一项随机，开放标签，干预性研究，以评估饮食结构对接受强化胰岛素治疗的肥胖2型糖尿病患者体重增加的影响。
6. Lixisenatide in type 1 diabetes: A randomised control trial of the effect of lixisenatide on post‐meal glucose excursions and glucagon in type 1 diabetes patients [O] . Chitrabhanu Ballav, Archana Dhere, Irene Kennedy, 2020

机译：利西拉肽治疗1型糖尿病：利西拉肽对1型糖尿病患者餐后血糖和胰高血糖素影响的随机对照试验
7. Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive patients with type 2 diabetes (SUSTAIN 4): a randomised, open-label, parallel-group, multicentre, multinational, phase 3a trial [O] . Vanita R Aroda, Stephen C Bain, Bertrand Cariou, 2017

机译：每周半蛋白质的疗效和安全性与胰岛素 - 野生患者2型糖尿病患者的二甲双胍（有或没有磺酰脲类）加载作用 - 每日胰岛素冰壶（携带4）：随机，开放标签，平行组，多期，跨国，第3A期试验

Postprandial renal haemodynamic effect of lixisenatide vs once-daily insulin-glulisine in patients with type 2 diabetes on insulin-glargine: An 8-week, randomised, open-label trial

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