Irinotecan-Eluting 75-150-mu m Embolics Lobar Chemoembolization in Patients with Colorectal Cancer Liver Metastases: A Prospective Single-Center Phase I Study

Fereydooni Arash; Letzen Brian; Ghani Mansur A.; Miszczuk Milena A.; Huber Steffen; Chapiro Julius; Schlachter Todd; Geschwind Jean-Francois; Georgiades Christos

首页> 外文期刊>Journal of vascular and interventional radiology: JVIR >Irinotecan-Eluting 75-150-mu m Embolics Lobar Chemoembolization in Patients with Colorectal Cancer Liver Metastases: A Prospective Single-Center Phase I Study

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Irinotecan-Eluting 75-150-mu m Embolics Lobar Chemoembolization in Patients with Colorectal Cancer Liver Metastases: A Prospective Single-Center Phase I Study

机译：伊替康丹出现75-150-MU M栓塞植物栓塞肝脏转移患者的栓塞式栓塞：我研究的预期单中心阶段

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Purpose: The primary end point of this trial was to determine the feasibility and safety of transarterial chemoembolization with the use of 75-150-mu m drug-eluting embolics loaded with irinotecan (DEE-IRI) for the treatment of metastatic colorectal cancer (CRC) refractory to systemic chemotherapy.

机译：目的：该试验的主要终点是测定常规化疗栓塞的可行性和安全性，其使用75-150 - 米米的药物洗脱栓塞，用于治疗转移结直肠癌（CRC ）对全身化疗的难以解决。

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《Journal of vascular and interventional radiology: JVIR》 |2018年第12期|共8页
作者
Fereydooni Arash; Letzen Brian; Ghani Mansur A.; Miszczuk Milena A.; Huber Steffen; Chapiro Julius; Schlachter Todd; Geschwind Jean-Francois; Georgiades Christos;
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作者单位

Yale Univ Sch Med Dept Radiol &

Biomed Imaging Anlyan Ctr 300 Cedar St N312A New Haven CT;

Yale Univ Sch Med Dept Radiol &

Biomed Imaging Anlyan Ctr 300 Cedar St N312A New Haven CT;

Yale Univ Sch Med Dept Radiol &

Biomed Imaging Anlyan Ctr 300 Cedar St N312A New Haven CT;

Yale Univ Sch Med Dept Radiol &

Biomed Imaging Anlyan Ctr 300 Cedar St N312A New Haven CT;

Yale Univ Sch Med Dept Radiol &

Biomed Imaging Anlyan Ctr 300 Cedar St N312A New Haven CT;

Yale Univ Sch Med Dept Radiol &

Biomed Imaging Anlyan Ctr 300 Cedar St N312A New Haven CT;

Yale Univ Sch Med Dept Radiol &

Biomed Imaging Anlyan Ctr 300 Cedar St N312A New Haven CT;

Johns Hopkins Univ Hosp Russell H Morgan Dept Radiol &

Radiol Sci Div Vasc &

Intervent Radiol;

Johns Hopkins Univ Hosp Russell H Morgan Dept Radiol &

Radiol Sci Div Vasc &

Intervent Radiol;

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正文语种 eng
中图分类放射医学;
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专利

1. Irinotecan-Eluting 75-150-mu m Embolics Lobar Chemoembolization in Patients with Colorectal Cancer Liver Metastases: A Prospective Single-Center Phase I Study [J] . Fereydooni Arash, Letzen Brian, Ghani Mansur A., Journal of vascular and interventional radiology: JVIR . 2018,第12期

机译：伊替康丹出现75-150-MU M栓塞植物栓塞肝脏转移患者的栓塞式栓塞：我研究的预期单中心阶段
2. Intraarterial hepatic chemoembolization of liver metastases from colorectal cancer adopting irinotecan-eluting beads: results of a phase II clinical study. [J] . Fiorentini G, Aliberti C, Turrisi G, In vivo. . 2007,第6期

机译：采用伊立替康洗脱珠的大肠癌肝转移的肝内动脉化疗栓塞：II期临床研究的结果。
3. Transcatheter arterial chemoembolization (TACE) of colorectal cancer liver metastases by irinotecan-eluting microspheres in a salvage patient population [J] . HuppertP., WenzelT., WietholtzH. Cardiovascular and Interventional Radiology: A Journal of Imaging in Diagnosis and Treatment . 2014,第1期

机译：挽救患者人群中伊立替康洗脱微球对大肠癌肝转移的经导管动脉化疗栓塞（TACE）
4. High-Depth Sequencing of Over 750 Genes Supports Linear Progression of Primary Tumors and Metastases in the Majority of Patients with Liver-Limited Metastatic Colorectal Cancer [C] . Simeen Malik, Iain Beehuat Tan, Kalpana Ramnarayanan, International Molecular Medicine Tri-Conference. . 2015

机译：超过750个基因的高深度测序支持肝脏有限转移性结直肠癌大多数患者的原发性肿瘤和转移的线性进展
5. Cost-effectiveness of imaging and surgery in patients with colorectal cancer liver metastases. [D] . Gazelle, Guy Scott. 1999

机译：大肠癌肝转移患者影像和手术的成本效益。
6. Treatment strategies in colorectal cancer patients with initially unresectable liver-only metastases a study protocol of the randomised phase 3 CAIRO5 study of the Dutch Colorectal Cancer Group (DCCG) [O] . Joost Huiskens, Thomas M van Gulik, Krijn P van Lienden, 2015

机译：最初无法切除的仅肝转移的大肠癌患者的治疗策略荷兰大肠癌组（DCCG）的随机3期CAIRO5研究的研究方案
7. 03:18 PM Abstract No. 104 Irinotecan drug-eluting beads chemoembolization (DEBIRI) plus mFolfox6 as front-line treatment in patients with non resectable liver dominant metastases of colorectal cancer (FFCD 1201 phase II trial): result of single-arm, open-label phase II study [O] . O. Pellerin, S. Pernot, V. Vidal, 2019

机译：03:18 PM摘要104 Irinotecan药物洗脱珠子化疗（Debiri）加上MFOLFOX6作为结直肠癌不可切除肝脏常量转移患者的前线治疗（FFCD 1201期试验）：单臂，开放的结果-Label期II研究

Irinotecan-Eluting 75-150-mu m Embolics Lobar Chemoembolization in Patients with Colorectal Cancer Liver Metastases: A Prospective Single-Center Phase I Study

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