Effects of nebivolol versus carvedilol on left ventricular function in patients with chronic heart failure and reduced left ventricular systolic function.

Lombardo RM; Reina C; Abrignani MG; Rizzo PA; Braschi A; De Castro S

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Effects of nebivolol versus carvedilol on left ventricular function in patients with chronic heart failure and reduced left ventricular systolic function.

机译：奈比洛尔和卡维地洛对慢性心力衰竭和左心收缩功能降低的患者左心功能的影响。

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BACKGROUND: Beta-adrenoceptor antagonist (beta-blocker) therapy results in a significant improvement in left ventricular (LV) systolic function and prognosis in patients with chronic heart failure. Both carvedilol and nebivolol produce hemodynamic and clinical benefits in chronic heart failure, but it is unknown whether their peculiar pharmacologic properties produce different effects on LV function. OBJECTIVE: To assess the effects on LV function of nebivolol compared with carvedilol in patients with chronic heart failure and reduced LV systolic function. METHODS: Seventy patients with a LV ejection fraction

机译：背景：β-肾上腺素能受体拮抗剂（β-受体阻滞剂）疗法可显着改善慢性心力衰竭患者的左心室（LV）收缩功能和预后。卡维地洛和奈比洛尔都可在慢性心力衰竭中产生血液动力学和临床益处，但尚不清楚它们独特的药理性质是否会对左室功能产生不同的影响。目的：评估奈韦洛尔与卡维地洛相比对慢性心力衰竭和左室收缩功能降低的患者的左室功能的影响。方法：将70例左室射血分数<或= 40％且在纽约心脏协会（NYHA）功能性II级或III级患者中随机分配接受卡维地洛或奈必洛尔治疗6个月。在基线和治疗6个月后，通过生化和血液学调查，ECG，24小时动态心电图监测，超声心动图，通气功能测量和6分钟步行测试对所有患者进行临床评估。结果：与基线值相比，卡维地洛的左室收缩末期容积减少，左室射血分数增加（从79 +/- 38mL增加到73 +/- 43mL，从33％+/- 6％到37％+/- 11 ％）和奈比洛尔组（从72 +/- 35mL到66 +/- 32mL和从34％+/- 7％到38％+/- 10％），尽管组间差异无统计学意义。心电图数据显示两组静息HR均降低（卡维地洛从83 +/- 20 bpm降至66 +/- 11 bpm，奈比洛尔从81 +/- 15 bpm降至65 +/- 11 bpm; p <0.001 vs两组的基线），但PQ，QRS和QT间隔无差异。血液学（尤其是N端脑钠肽前体），动态心电图监测（HR除外）和呼吸功能数据在治疗6个月后两组均无明显变化。两组的SBP和DBP均降低。两组的平均NYHA功能类别均较基线水平有所降低（卡维地洛从2.5 +/- 0.5降至2.2 +/- 0.5 [p <0.05]，奈比洛尔从2.3 +/- 0.4降至2.2 +/- 0.5 [不重要]）。 6分钟步行测试显示两组步行距离都有增加的趋势。在治疗的6个月中，两组之间未观察到不良事件的显着差异。结论：奈比洛尔在有症状的慢性心力衰竭和左室收缩功能降低的患者中与卡维地洛同样有效。

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《American journal of cardiovascular drugs: drugs, devices, and other interventions》 |2006年第4期|共5页
作者
Lombardo RM; Reina C; Abrignani MG; Rizzo PA; Braschi A; De Castro S;
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中图分类药学;
关键词
physiological aspects; carvedilol; Calcium Leucovorin; nebivolol; Chronic;

机译：生理方面;卡维地洛;白细胞钙钙;奈必洛尔;慢性;

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1. Effects of nebivolol versus carvedilol on left ventricular function in patients with chronic heart failure and reduced left ventricular systolic function. [J] . Lombardo RM, Reina C, Abrignani MG, American journal of cardiovascular drugs: drugs, devices, and other interventions . 2006,第4期

机译：奈比洛尔和卡维地洛对慢性心力衰竭和左心收缩功能降低的患者左心功能的影响。
2. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. [J] . McMurray JJ, Ostergren J, Swedberg K, The Lancet . 2003,第9386期

机译：服用血管紧张素转换酶抑制剂的坎地沙坦对慢性心力衰竭和左室收缩功能降低的患者的影响：CHARM-Added试验。
3. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial. [J] . Granger CB, McMurray JJ, Yusuf S, The Lancet . 2003,第9386期

机译：坎地沙坦对慢性心力衰竭和左心室收缩功能降低的患者具有血管紧张素转换酶抑制剂的影响：CHARM-Alternative试验。
4. Effects of optimized heart failure medication on central sleep apnea with Cheyne-Stokes respiration pattern in chronic heart failure with reduced left-ventricular ejection fraction [C] . C Schoebel, I Fietze, T Penzel Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2019

机译：优化的心力衰竭药物对慢性心力衰竭左心室射血分数降低的Cheyne-Stokes呼吸模式对中枢性睡眠呼吸暂停的影响
5. Effects of Pacing Site on Global and Regional Left Ventricular Function in the Setting of Dyssynchronous Heart Failure [D] . Howard, Elliot Jacob 2011

机译：心律失常时起搏部位对整体和区域左心室功能的影响
6. Carvedilol and nebivolol improve left ventricular systolic functions in patients with non-ischemic heart failure [O] . Mustafa Karabacak, Abdullah Doğan, Şenol Tayyar, 2015

机译：卡维地洛和奈必洛尔可改善非缺血性心力衰竭患者的左心室收缩功能
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机译：心力衰竭：左心室收缩功能障碍患者的评估和护理。临床实践指南第11号;心力衰竭：左心室收缩功能障碍患者的治疗。临床医生快速参考指南第11号;与心脏病共存：是心衰吗？患者和家庭指南

Effects of nebivolol versus carvedilol on left ventricular function in patients with chronic heart failure and reduced left ventricular systolic function.

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