SYNTHESIS AND *H NMR STRUCTURAL CHARACTERIZATION OF A SERIES OF 5 SUBSTITUTED ISATIN THIOSEMI-CARBAZONE AND SEMICARBAZONE COMPOUNDS

摘要

This work will present the synthesis and ~1H NMR characterization of three series of 5-substituted isatin thiosemicarbazone compounds. The 5-nitroisatin, 5-fluoroisatin and 5-sulfonic acid isatin substrates were reacted with thiosemicarbazide, 4-methyl· 3-thiosemicarbazide, 4-ethyl-3-thiosemicarbazone, 4-benzyl-3-thiosemicarbazone，4-phenyl-3-thiosemicarbazide，4,4-dimethyl-3-thiosemicarbazide, semicarbazide, and 4-phenyl-3-semicarbazide to give three series of thiosemicarbazone and semicarbazone compounds. Studies using ~1H NMR show the presence of intramolecular hydrogen bonding in solution for all of the 5-substituted isatin thiosemicarbazone compounds.