Probabilistic expression of spatially varied amino acid dimers into general form of Chou's pseudo amino acid composition for protein fold recognition

摘要

Background: Identification of the tertiary structure (3D structure) of a protein is a fundamental problem in biology which helps in identifying its functions. Predicting a protein's fold is considered to be an intermediate step for identifying the tertiary structure of a protein. Computational methods have been applied to determine a protein's fold by assembling information from its structural, physicochemical and/or evolutionary properties.