Inhibitory Effect of Procyanidin B2 on Melanin Biosynthesis in Melanocytes

摘要

This study investigated the skin depigmenting activity of procyanidin B2 by using melanocytes. The results revealed that procyanidin B2 showed potent inhibitory effects on melanin production in melanocytes without there being any cell toxicity. The inhibitory effect on melanin production by procyanidin B2 was greater than that of arbutin at the same concentration. Further, procyanidin B2 potently inhibited the tyrosinase and TRP-2 expressions in a-MSH stimulated B16 melanoma cells. These results suggested that procyanidin B2 might be useful as skin depigmenting agent.