One-pot synthesis and biological and catalytic applications of organometallic complexes involving oxazolines and (R)/(S)-a-phenylethylamine

摘要

The crystal structures of zinc complexes 1 and 3 were determined following synthesis via a one-pot method involving the reaction of 2-hydro-6-methyl-nicotinonitrile and 2-cyanopyridine with different l-amino alcohols mediated by 120-130 mol% ZnCl2. Copper complex 4 and cobalt complex 5 were prepared by reacting (R)/(S)-a-phenylethylamine with dimethyl dichloride silane in the presence of 52 mol% CuCl2 or 50 mol% CoCl2 as the third components. Crystalline compounds 1-5 were all characterized by elemental analysis, IR and NMR spectroscopies, and X-ray diffraction. Then, complexes 1 and 3-5 were evaluated for cytotoxicity against the human tumor cell line SMMC-7721 and were also used as catalysts in the nucleophilic addition reaction of trimethylsilonitrile with diphenylketimine. Both complexes exhibited anticancer activity against the human tumor cell line SMMC-7721 and showed enhanced catalytic effects.