Incidence, prevalence, and mortality of Adamantiades‐Beh?et's disease in Korea: a nationwide, population‐based study (2006–2015)

摘要

Abstract Background The epidemiology of Adamantiades‐Beh?et's disease varies among ethnic populations worldwide. Trends in the incidence of Adamantiades‐Beh?et's disease have not been investigated based on the Korean National Health Insurance database. Objectives This study investigated the incidence and mortality of Adamantiades‐Beh?et's disease by age using nationwide population data in Korea. Methods A nationwide population‐based cohort study was performed using the Korean National Health Insurance Claims Database from 2006 to 2015. The incidence of Adamantiades‐Beh?et's disease was calculated by age, sex, calendar year and habitat. And comorbid metabolic diseases were also analysed in patients with Adamantiades‐Beh?et's disease. Results The annual incidence of Adamantiades‐Beh?et's disease per 100?000 person‐years was 3.976 (2.587 for males and 5.373 for females) from 2006 to 2015. The incidence of Adamantiades‐Beh?et's disease peaked among people in their 40s (6.561 per 100?000 person‐years). Incidence was significantly higher in subjects with comorbid metabolic conditions, such as diabetes mellitus, hypertension and dyslipidemia. The mortality rate per 1000 person‐years increased with age in patients with Adamantiades‐Beh?et's disease. Conclusions This study showed the incidence, prevalence and mortality of Adamantiades‐Beh?et's disease. Metabolic conditions increased the risk of Adamantiades‐Beh?et's disease among Koreans.