Isolation and Enzyme Inhibitory Studies of Steroids and Alkaloidal Steroid Saponins from Solanum surattense Burm.f.

摘要

Two new alkaloidal steroid glycosides; solanoid A and B (1 and 2), along with two known alkaloidal steroid glycosides; solamargine (3) and khasianine (4) a known steroidal saponin; dioscin (5), a benzoylated steroid, carpesterol (6) methyl caffeate (7), ferulic acid (8) and oleic acid (9) were isolated from the methanolic extract of Solanum surattense. The new compounds were identified through 1D and 2D NMR techniques, and high resolution mass spectrometric analysis, while the known compounds were elucidated due to 1D NMR, mass spectrometry and in comparison with the literature values of their spectroscopic data. Compounds 1-6 were evaluated for anti-alpha-glucosidase, anti-urease and antioxidant activity, where only compound 6 inhibited the activity of alpha-glucosidase with IC50 value of 42.26 mu M.