Review article: potential mechanisms of action of rifaximin in the management of irritable bowel syndrome with diarrhoea

摘要

BackgroundThe role of gut microbiota in the pathophysiology of irritable bowel syndrome (IBS) is supported by various lines of evidence, including differences in mucosal and faecal microbiota between patients with IBS and healthy individuals, development of post-infectious IBS, and the efficacy of some probiotics and nonsystemic antibiotics (e.g. rifaximin).