Supraspinal inhibitory effects of chimeric peptide MCRT on gastrointestinal motility in mice

摘要

ObjectivesChimeric peptide MCRT, based on morphiceptin and PFRTic-NH2, was a bifunctional ligand of - and -opioid receptors (MOR-DOR) and produced potent analgesia in tail-withdrawal test. The study focused on the supraspinal effects of morphiceptin, PFRTic-NH2 and MCRT on gastrointestinal motility. Moreover, opioid receptor antagonists, naloxone (non-selective), cyprodime (MOR selective) and naltrindole (DOR selective) were utilized to explore the mechanisms.