TUG1 promotes lens epithelial cell apoptosis by regulating miR-421/caspase-3 axis in age-related cataract

Li Guoxing; Song Huiyang; Chen Lei; Yang Weihua; Nan Kaihui; Lu Peirong

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TUG1 promotes lens epithelial cell apoptosis by regulating miR-421/caspase-3 axis in age-related cataract

机译：Tug1通过调节年龄相关性白内障的miR-421 / caspase-3轴来促进镜片上皮细胞凋亡

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摘要

Background: Age-related cataract is among the most common chronic disorders of ageing and the apoptosis of lens epithelial cells contributes to non-congenital cataract development. We amid to explore the role of TUG1 and miR-421 in the age-related cataract.

机译：背景：年龄相关的白内障是衰老最常见的慢性疾病之一，透镜上皮细胞的凋亡有助于非先天性白内障发育。我们在探索Tug1和MiR-421在与年龄相关的白内障中的作用。

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来源
《Journal of Structural Biology 》 |2017年第3期| 共8页
作者
Li Guoxing; Song Huiyang; Chen Lei; Yang Weihua; Nan Kaihui; Lu Peirong;
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作者单位

Soochow Univ Affiliated Hosp 1 188 Shizi St Suzhou 215006 Jiangsu Peoples R China;

Wenzhou Med Univ Eye Hosp 270 Xueyuan Xi Rd Wenzhou 325027 Zhejiang Peoples R China;

Soochow Univ Affiliated Hosp 1 188 Shizi St Suzhou 215006 Jiangsu Peoples R China;

Soochow Univ Affiliated Hosp 1 188 Shizi St Suzhou 215006 Jiangsu Peoples R China;

Wenzhou Med Univ Eye Hosp 270 Xueyuan Xi Rd Wenzhou 325027 Zhejiang Peoples R China;

Soochow Univ Affiliated Hosp 1 188 Shizi St Suzhou 215006 Jiangsu Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类生物形态学 ;
关键词
Age-related cataract; Lens epithelial cell; TUG1 MiR-421 Caspase-3;

机译：年龄相关的白内障;镜片上皮细胞;Tug1 miR-421 caspase-3;

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专利

1. TUG1 promotes lens epithelial cell apoptosis by regulating miR-421/caspase-3 axis in age-related cataract [J] . Li Guoxing, Song Huiyang, Chen Lei, Journal of Structural Biology . 2017 ,第3期

机译：Tug1通过调节年龄相关性白内障的miR-421 / caspase-3轴来促进镜片上皮细胞凋亡
2. miR-211 promotes lens epithelial cells apoptosis by targeting silent mating-type information regulation 2 homolog 1 in age-related cataracts [J] . Bo Lu1, Ian T.Christensen2, Li-Wei Ma1, 国际眼科杂志：英文版 . 2018 ,第002期

机译：miR-211通过针对年龄相关性白内障的沉默交配型信息调节2同源物1促进晶状体上皮细胞凋亡
3. miR-24-p53 pathway evoked by oxidative stress promotes lens epithelial cell apoptosis in age-related cataracts [J] . Lu Bo, Christensen Ian T., Ma Li-Wei, Molecular medicine reports . 2018 ,第4aPta1期

机译：氧化应激引起的miR-24-p53途径促进了与年龄相关性白内障的镜片上皮细胞凋亡
4. Caspase-8 Regulates Caspase-3 and Rb Respectively in Fas- and Actinomycin D-Mediated Apoptosis Pathway in Human Hepatoma Bel-7402 Cells [C] . Yu Wang, Liguang Sun, Chunhui Xia, International Conference on Biomedical Engineering and Informatics . 2008

机译：Caspase-8分别在人肝癌BEL-7402细胞中分别在Fas-和放线菌素D介导的凋亡途径中调节Caspase-3和Rb
5. TGF-beta promotes cancer progression through the xIAP:TAB1:TAK1:IKK axis in mammary epithelial cells. [D] . Neil, Jason Robert. 2008

机译：TGF-β通过xIAP：TAB1：TAK1：IKK轴促进乳腺上皮细胞中的癌症进展。
6. miR-211 promotes lens epithelial cells apoptosis by targeting silent mating-type information regulation 2 homolog 1 in age-related cataracts [O] . Bo Lu, Ian T. Christensen, Li-Wei Ma, 2018

机译：miR-211通过针对年龄相关性白内障的沉默交配型信息调节2同源物1促进晶状体上皮细胞凋亡
7. CircHIPK3 knockdown suppresses E2F3 expression to inhibit the viability and promote the apoptosis of lens epithelial cells in age-related cataract by sponging miR-499a-5p [O] . Qichao Han, Rong Zhang, Lan Ma, 2021

机译：Circhipk3敲低抑制E2F3表达，以抑制活力并通过冲水MiR-499A-5P抑制年龄相关性白内障透镜上皮细胞的凋亡

TUG1 promotes lens epithelial cell apoptosis by regulating miR-421/caspase-3 axis in age-related cataract

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