Allopurinol-induced DRESS syndrome with a histologic pattern consistent with interstitial granulomatous drug reaction

摘要

We read the case reported by Suran and Christopher1 with great interest because we recently treated a similar case of drug rash with eosinophilia and systemic symptoms (DRESS syndrome) with a histologic pattern consistent with an interstitial granulomatous drug reaction (IGDR).A 45-year-old man was admitted to our department with a pruritic rash and facial edema present for 3 days. The medical history included hyperuri-cemia; the patient was treated with allopurinol for 2 months. The physical examination demonstrated marked generalized erythema with multiple overlying papules and plaques over the entire body and cervical lymphadenop-athy (Figs. 1, 2).