Impact of column and stationary phase properties on the productivity in chiral preparative LC

Forssén Patrik; Fornstedt Torgny

摘要

Abstract > By generating 1500 random chiral separation systems, assuming two‐site Langmuir interactions, we investigated numerically how the maximal productivity ( P <sub>R,max</sub> ) was affected by changes in stationary phase adsorption properties. The relative change in P <sub>R,max</sub> , when one adsorption property changed 10%, was determined for each system and for each studied parameter the corresponding productivity change distribution of the systems was analyzed. We could conclude that there is no reason to have columns with more than 500 theoretical plates and larger selectivity than 3. More specifically, we found that changes in selectivity have a major impact on P <sub>R,max</sub> if it is below ～2 and, interestingly, increasing selectivity when it is above ～3 decreases P <sub>R,max</sub> . Increase in relative saturation capacity will have a major impact on P <sub>R,max</sub> if it is below ～40%, but only modest above this percent. Increasing total monolayer saturation capacity, or decreasing the first eluting enantiomer's retention factor, will have a modest effect on P <sub>R,max</sub> and increased efficiency will have almost no effect at all on P <sub>R,max</sub> unless it is below ～500 theoretical plates. Finally, we showed that chiral columns with superior analytic performance might have inferior preparative performance, or vice versa. It is, therefore, not possible to assess columns based on their analytical performance alone. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >通过生成1500个随机的手性分离系统，假设双站点朗马尔互动，我们如何计算方法最大生产率（ p </ i> <sub> r，max </ sub>）受固定相吸附特性的变化的影响。对于每个系统确定一个吸附性能发生10％时， p </ i> <sub> r，max </ sub>的相对变化。每个系统确定每个研究的参数，系统的相应生产率变化分布分析。我们可以得出结论，没有理由具有超过500个理论板的柱和比3更大的选择性。更具体地，我们发现选择性的变化对 P </ i> <sub> r，最大</ sub>如果它低于〜2并且有趣的是，当它高于〜3时，有趣的选择性会降低 p </ i> <sub> r，max </ sub>。相对饱和容量的增加将对 p </ i> <sub> r，max </ sub>如果低于〜40％，但仅适用于此百分比。增加总单层饱和容量，或减少第一洗脱对映体的保留因子，对 p </ i> <sub> r，max </ sub>并提高效率几乎没有效果 p </ i> <sub> r，max </ sub>，除非它低于约500个理论板。最后，我们表明，具有卓越分析性能的手性柱可能具有较差的制备性能，反之亦然。因此，不可能仅基于其分析性能来评估列。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35800/'>《Journal of separation science.》</a> <b style="margin: 0 2px;">|</b><span>2018年第6期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Forssén Patrik&option=202" target="_blank" rel="nofollow">Forssén Patrik;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Fornstedt Torgny&option=202" target="_blank" rel="nofollow">Fornstedt Torgny;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Engineering and Chemical SciencesKarlstad UniversityKarlstad Sweden;</p> <p>Department of Engineering and Chemical SciencesKarlstad UniversityKarlstad Sweden;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/159.html" title="化学">化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=enantiomers&option=203" rel="nofollow">enantiomers;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=preparative chromatography&option=203" rel="nofollow">preparative chromatography;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=process optimization&option=203" rel="nofollow">process optimization;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=productivity&option=203" rel="nofollow">productivity;</a> </p> <div class="translation"> 机译：对映体;制备色谱;过程优化;生产率; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025847013.html">Impact of column and stationary phase properties on the productivity in chiral preparative LC</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Forssén Patrik&option=202" 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href="/patent-detail/06120106177934.html">用于提高相位噪声性能的正交LC压控振荡器结构</a> <b>[P]</b> . <span> 中国专利： CN101986556A </span> <span> . 2011-03-16</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120111880206.html">用于减少干旱对种植物性能的影响的系统，用于制备该系统的组分I的方法，使用该系统来减少干旱对种植物性能的影响的方法及其中使用的农具</a> <b>[P]</b> . <span> 中国专利： CN111868013A </span> <span> . 2020-10-30</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130443849312.html">LC Liquid chromatographic ligand exchange chiral stationary phases chiral columns packed with the ligand exchange chiral stationary phases</a> <b>[P]</b> . <span> 外国专利：  KR20030077238A </span> <span> . 2003-10-01</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：LC液相色谱配体交换手性固定相填充有配体交换手性固定相的手性柱 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130441605515.html">CHIRAL CROWN ETHER-BASED LC CHIRAL STATIONARY PHASES AND CHIRAL COLUMNS THEREOF, AND METHOD FOR PRODUCING THE SAME</a> <b>[P]</b> . <span> 外国专利：  KR20040080034A </span> <span> . 2004-09-18</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于手性冠醚的LC手性固定相及其手性柱及其制备方法 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130452011923.html">Chiral stationary phase and LC-filled chiral column for LC for optical division of racemic compounds having a primary amino group</a> <b>[P]</b> . <span> 外国专利：  KR19990075668A </span> <span> . 1999-10-15</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于LC的手性固定相和LC填充手性色谱柱，用于光学拆分具有伯氨基的外消旋化合物 </span> </p> </li> </ul> 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