Simultaneous determination of free and total choline and        <sc >l‐</sc>l‐        carnitine in infant formula using hydrophilic interaction liquid chromatography with tandem mass spectrometry

Zheng Hong; Yu Wenjiang; Xue Xia; Guo Zhimou; Liu Yanfang; Yang Guosheng; Liu Yanming; Zhu Jianhua

摘要

Abstract > A quick, simple, and reliable method was developed for the simultaneous determination of free and total choline and <sc>l‐</sc> carnitine in infant formula employing a novel hydrophilic interaction liquid chromatography with tandem mass spectrometry method. Microwave‐assisted hydrolysis was used to shorten the hydrolysis time to only 15?min. A novel Click XIon zwitterionic stationary phase was chosen because it gave better retention, perfect resolution, and sharper symmetrical peaks compared to traditional columns. The matrix effect under different experimental conditions was evaluated by using the matrix effect factor, which employs stable isotopically labeled internal standards and is more appropriate for evaluating the matrix effect related to endogenous analytes. The accuracy and precision of the method were validated with certified reference materials. The fortified recovery values for choline and <sc>l‐</sc> carnitine were between 85.0 and 104% with relevant standard deviations 5.0%. The established method was applied to the analysis of real infant formulas, demonstrating its applicability and feasibility. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >快速，简单，可靠的方法，用于同时测定自由和总胆碱和<sc> l - </ sc>在婴儿配方中的肉碱，采用新的亲水性相互作用液相色谱法，具有串联质谱法。使用微波辅助水解将水解时间缩短至仅15Ω分钟。选择一个小说单击XION两倍固定阶段，因为它具有更好的保留，完美的分辨率和与传统色谱柱相比的对称峰值。通过使用基质效应因子评价不同实验条件下的基质效应，其采用稳定的同位素标记的内标，更适合评估与内源分析物相关的基质效果。该方法的准确性和精度验证了认证参考资料。胆碱和<sc> l - </ sc>肉碱的强化恢复值在85.0和104％之间，相关标准偏差为5.0％。建立的方法应用于实际婴儿公式的分析，证明了其适用性和可行性。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35800/'>《Journal of separation science.》</a> <b style="margin: 0 2px;">|</b><span>2018年第16期</span><b style="margin: 0 2px;">|</b><span>共10页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zheng Hong&option=202" target="_blank" rel="nofollow">Zheng Hong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yu Wenjiang&option=202" target="_blank" rel="nofollow">Yu Wenjiang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xue Xia&option=202" target="_blank" rel="nofollow">Xue Xia;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Guo Zhimou&option=202" target="_blank" rel="nofollow">Guo Zhimou;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Yanfang&option=202" target="_blank" rel="nofollow">Liu Yanfang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Guosheng&option=202" target="_blank" rel="nofollow">Yang Guosheng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Yanming&option=202" target="_blank" rel="nofollow">Liu Yanming;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhu Jianhua&option=202" target="_blank" rel="nofollow">Zhu Jianhua;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Shandong Institute for Food and Drug ControlJinan China;</p> <p>Shandong Institute for Food and Drug ControlJinan China;</p> <p>Shandong Institute for Food and Drug ControlJinan China;</p> <p>Dalian Institute of Chemical PhysicsChinese Academy of ScienceLiaoning China;</p> <p>Dalian Institute of Chemical PhysicsChinese Academy of ScienceLiaoning China;</p> <p>School of Chemistry and Chemical EngineeringShandong UniversityJinan China;</p> <p>Shandong Institute for Food and Drug ControlJinan China;</p> <p>Shandong Institute for Food and Drug ControlJinan China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/159.html" title="化学">化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=carnitine&option=203" rel="nofollow">carnitine;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=choline&option=203" rel="nofollow">choline;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=hydrophilic interaction liquid chromatography&option=203" rel="nofollow">hydrophilic interaction liquid chromatography;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=mass spectrometry&option=203" rel="nofollow">mass spectrometry;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=matrix effects&option=203" rel="nofollow">matrix effects;</a> </p> <div class="translation"> 机译：肉碱;胆碱;亲水相互作用液相色谱;质谱;矩阵效应; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div 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Simultaneous determination of free and total choline and l‐l‐ carnitine in infant formula using hydrophilic interaction liquid chromatography with tandem mass spectrometry

摘要